Altered adult hippocampal neurogenesis in the YAC128 transgenic mouse model of Huntington disease
Autor: | Mohamed Ghilan, Jessica M. Simpson, Brian R. Christie, Mahmoud A. Pouladi, Yuanyun Xie, Joana Gil-Mohapel, Michael R. Hayden |
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Rok vydání: | 2011 |
Předmět: |
Genetically modified mouse
medicine.medical_specialty Subventricular zone Neurogenesis Transgene Hippocampus Mice Transgenic Nerve Tissue Proteins Hippocampal formation Biology Adult neurogenesis lcsh:RC321-571 Mice Internal medicine Neuroplasticity medicine Animals Humans lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Cell proliferation Huntingtin Protein Neuronal Plasticity Dentate gyrus Nuclear Proteins YAC128 transgenic mice Disease Models Animal Huntington Disease Endocrinology medicine.anatomical_structure nervous system Neurology Dentate Gyrus Cognition Disorders Neuroscience |
Zdroj: | Neurobiology of Disease, Vol 41, Iss 2, Pp 249-260 (2011) |
ISSN: | 0969-9961 |
Popis: | Perturbations in neurogenesis in the adult brain have been implicated in impaired learning and memory. In the present study, we investigated which stages of the neurogenic process are affected in the transgenic YAC128 mouse model of Huntington disease (HD). Hippocampal neuronal proliferation was altered in the dentate gyrus (DG) of YAC128 mice as compared with wild-type (WT) littermate controls in early symptomatic to end-stage mice. In addition, we detected a significantly lower number of immature neurons in the DG of young, pre-symptomatic YAC128 mice. This decrease in neuronal differentiation persisted through the progression of the disease, and resulted in an overall reduction in the number of new mature neurons in the DG of YAC128 mice. There were no changes in cell proliferation and differentiation in the subventricular zone (SVZ). In this study, we demonstrate decreases in neurogenesis in the DG of YAC128 mice, and these deficits may contribute to the cognitive abnormalities observed in these animals. |
Databáze: | OpenAIRE |
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