A PEGylated megamer-based microRNA delivery system activatable by stepwise microenvironment stimulation

Autor:	Shiyi Shao, Meng Wang, Guping Tang, Junming Huang, Xinyu Zhao, Tingbo Liang, Qida Hu, Hongzhen Bai, Wangteng Wu
Rok vydání:	2019
Předmět:	Dendrimers Transplantation Heterologous Mice Nude Stimulation 010402 general chemistry 01 natural sciences Catalysis Polyethylene Glycols Mice Cell Line Tumor microRNA Materials Chemistry medicine Animals Humans Drug Carriers Tumor microenvironment 010405 organic chemistry Chemistry Liver Neoplasms Metals and Alloys General Chemistry medicine.disease 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Transplantation MicroRNAs Ceramics and Composites Cancer research Nanoparticles Delivery system Liver cancer
Zdroj:	Chemical Communications. 55:9363-9366
ISSN:	1364-548X 1359-7345
DOI:	10.1039/c9cc03846a
Popis:	We developed a biodegradable, oncosensitive, megamer-based delivery system for miRNA therapy. The miRNA nanotherapeutics, activatable by stepwise stimulation of acidity and reduction mimicking tumor microenvironment, efficiently improve liver-specific miR-122 expression, increasing the possibility of translational application of miR-122 therapy against liver cancer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc2d7ada233930c5b52abf863c60d7d https://doi.org/10.1039/c9cc03846a Zobrazit plný text záznamu