Experimental infection with H1N1 European swine influenza virus protects pigs from an infection with the 2009 pandemic H1N1 human influenza virus
| Autor: | Joaquim Segalés, José I. Núñez, Gerard E. Martín-Valls, Francesc Xavier Abad, Lorena Córdoba, Mariano Domingo, Albert Bensaid, Maria Montoya, Núria Busquets, Tufária Mussá, Elisa Crisci, Sonia Pina, Lorenzo Fraile, Natàlia Majó, Mónica Pérez-Maillo, Marta Pérez-Simó, Meritxell Simon-Grifé |
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| Rok vydání: | 2010 |
| Předmět: |
cross-protection
Swine viruses medicine.disease_cause influenza virus 0403 veterinary science Influenza A Virus H1N1 Subtype [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB] Veterinary virology Pandemic Influenza A virus Lung 0303 health sciences biology [SDV.BA]Life Sciences [q-bio]/Animal biology virus diseases 04 agricultural and veterinary sciences 3. Good health [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology RNA Viral [SDV.IMM]Life Sciences [q-bio]/Immunology Original Article [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Cross-protection 040301 veterinary sciences Orthomyxoviridae [SDV.BC]Life Sciences [q-bio]/Cellular Biology Human A(H1N1) 2009 H5N1 genetic structure Virus 03 medical and health sciences Orthomyxoviridae Infections medicine Animals Humans Pandemics 030304 developmental biology General Veterinary [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biology biology.organism_classification Virology human A(H1N1) 2009 Influenza A virus subtype H5N1 respiratory tract diseases [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics swine H1N1 Swine H1N1 [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Influenza virus Transmission and infection of H5N1 |
| Zdroj: | Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Veterinary Research Veterinary Research, BioMed Central, 2010, 41 (5), ⟨10.1051/vetres/2010046⟩ |
| ISSN: | 0928-4249 1297-9716 |
| Popis: | International audience; The recent pandemic caused by human influenza virus A(H1N1) 2009 contains ancestral gene segments from North American and Eurasian swine lineages as well as from avian and human influenza lineages. The emergence of this A(H1N1) 2009 poses a potential global threat for human health and the fact that it can infect other species, like pigs, favours a possible encounter with other influenza viruses circulating in swine herds. In Europe, H1N1, H1N2 and H3N2 subtypes of swine influenza virus currently have a high prevalence in commercial farms. To better assess the risk posed by the A(H1N1) 2009 in the actual situation of swine farms, we sought to analyze whether a previous infection with a circulating European avian-like swine A/Swine/Spain/53207/2004 (H1N1) influenza virus (hereafter referred to as SwH1N1) generated or not cross-protective immunity against a subsequent infection with the new human pandemic A/Catalonia/63/2009 (H1N1) influenza virus (hereafter referred to as pH1N1) 21 days apart. Pigs infected only with pH1N1 had mild to moderate pathological findings, consisting on broncho-interstitial pneumonia. However, pigs inoculated with SwH1N1 virus and subsequently infected with pH1N1 had very mild lung lesions, apparently attributed to the remaining lesions caused by SwH1N1 infection. These later pigs also exhibited boosted levels of specific antibodies. Finally, animals firstly infected with SwH1N1 virus and latter infected with pH1N1 exhibited undetectable viral RNA load in nasal swabs and lungs after challenge with pH1N1, indicating a cross-protective effect between both strains. |
| Databáze: | OpenAIRE |
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