Reply: Lesion network mapping predicts post-stroke behavioural deficits and improves localization
| Autor: | Thiebaut De Schotten, Michel, Nozais, Victor, Forkel, Stephanie, Foulon, Chris, Petit, Laurent, Salvalaggio, Alessandro, De Filippo De Grazia, Michele, Pini, Lorenzo, Zorzi, Marco, Corbetta, Maurizio |
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| Přispěvatelé: | Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
medicine.medical_specialty Brain Mapping business.industry [SDV]Life Sciences [q-bio] MEDLINE Network mapping Lesion Stroke 03 medical and health sciences 0302 clinical medicine Text mining Physical medicine and rehabilitation Post stroke Medicine Humans Neurology (clinical) medicine.symptom business Letters to the Editor 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Brain Brain-A Journal of Neurology Brain-A Journal of Neurology, Oxford University Press (OUP), 2021, 144 (4), pp.e36-e36. ⟨10.1093/brain/awab004⟩ |
| ISSN: | 1460-2156 0006-8950 |
| DOI: | 10.1093/brain/awab004⟩ |
| Popis: | International audience; Abstract In recent years, the field of functional neuroimaging has moved away from a pure localisationist approach of isolated functional brain regions to a more integrated view of these regions within functional networks. However, the methods used to investigate functional networks rely on local signals in grey matter and are limited in identifying anatomical circuitries supporting the interaction between brain regions. Mapping the brain circuits mediating the functional signal between brain regions would propel our understanding of the brain’s functional signatures and dysfunctions. We developed a method to unravel the relationship between brain circuits and functions: The Functionnectome. The Functionnectome combines the functional signal from fMRI with white matter circuits’ anatomy to unlock and chart the first maps of functional white matter. To showcase this method’s versatility, we provide the first functional white matter maps revealing the joint contribution of connected areas to motor, working memory, and language functions. The Functionnectome comes with an open-source companion software and opens new avenues into studying functional networks by applying the method to already existing datasets and beyond task fMRI. |
| Databáze: | OpenAIRE |
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