Cannabis and Cannabinoids: Kinetics and Interactions
| Autor: | Hanan Abramovici, Brian C. Foster, Cory S. Harris |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Drug
media_common.quotation_subject 030204 cardiovascular system & hematology Bioinformatics 03 medical and health sciences 0302 clinical medicine Cytochrome P-450 Enzyme System medicine Cytochrome P-450 Enzyme Inhibitors Humans Drug Interactions 030212 general & internal medicine Medical prescription Tetrahydrocannabinol Adverse effect media_common Cannabis Cytochrome P-450 Enzyme Inducers biology business.industry Cannabinoids General Medicine biology.organism_classification Metabolic enzymes Narcotic drugs business Cannabidiol medicine.drug |
| Zdroj: | The American journal of medicine. 132(11) |
| ISSN: | 1555-7162 |
| Popis: | Cannabis sativa and related products are widely used, but their potential to cause significant clinical interactions remains unclear, particularly for cannabinoid-enriched or otherwise concentrated products. The pharmacokinetics of most cannabis products is not known. Where information is known, there is wide variation. Extrapolation of limited clinical data is complicated by the complexity and variability of cannabis products as well as their delivery through various routes of administration. In vitro evidence shows that the major cannabinoids are substrates for numerous metabolic enzymes, including the cytochrome P450 metabolizing enzymes. Whereas many consumers consider cannabis products to be safe relative to alternative prescription or narcotic drugs, clinical reports of cannabis-related drug interactions and adverse events are increasing in frequency. Patients using these products, whether for medical or nonmedical purposes, together with conventional therapeutic agents may be at increased risk of adverse events, including therapeutic failure, and require enhanced monitoring. |
| Databáze: | OpenAIRE |
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