(13)C mixed triglyceride breath testing using infrared spectrometry: comparison of two devices in early infancy
| Autor: | Caron Blumenthal, Thomas Remer, Kevin J. Gaskin, D S Kent |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Cystic Fibrosis Spectrophotometry Infrared Medicine (miscellaneous) Infrared spectroscopy Sensitivity and Specificity 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Breath testing Reference Values Internal medicine Medicine Humans Pancreas Triglycerides Nutrition and Dietetics Chromatography Triglyceride business.industry Infant Reproducibility of Results Early infancy Absorption Physiological Endocrinology chemistry Breath Tests 030220 oncology & carcinogenesis Reference values Case-Control Studies 030211 gastroenterology & hepatology Exocrine Pancreatic Insufficiency Female business |
| Zdroj: | European journal of clinical nutrition. 70(8) |
| ISSN: | 1476-5640 |
| Popis: | The (13)C mixed triglyceride (MTG) breath test has been proposed for the non-invasive assessment of fat digestion and absorption. To evaluate whether reference values for the adequacy of fat absorption, set in the non-dispersive infrared spectrometry (NDIRS) system software proposed for healthy children and adults using the (13)C MTG breath test, are also applicable to infants of5 months of age.(13)C MTG breath testing with the NDIRS technique was performed in 54 healthy infants5 months of age (38 breast-fed, 16 formula-fed) and six infants diagnosed with cystic fibrosis (CF) using two NDIRS devices, IRIS and FANci2.The IRIS results were slightly higher compared with those assessed by the FANci2 device. The minimum cutoff value for pancreatic sufficiency (PS) is set as a cumulative percentage dose of (13)C recovered (cPDR) after 5 h of 13.0%. Pancreatic function status of six CF infants, three with PS and three with pancreatic insufficiency (PI), according to the 72 h-faecal fat balance test could be correctly determined with the (13)C MTG breath test using two NDIRS techniques. However, if these reference values had been used to determine pancreatic function status in healthy infants, 26 out of 54 infants would have been misclassified as pancreatic insufficient.Although the (13)C MTG breath test with the MS technique has the potential to be a suitable assessment of fat absorption in infants, the technique of NDIRS appears too insensitive in an infant population group. |
| Databáze: | OpenAIRE |
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