Prospective evaluation of corrected QT intervals and arrhythmias after exposure to epirubicin, cyclophosphamide, and 5-fluorouracil in women with breast cancer
| Autor: | Katsuhide Kitagawa, Megumi Inada, Sumio Morita, Yuichi Ando, Toyoaki Murohara, Yasuya Inden, Shigeo Iino, Masataka Sawaki, Kenji Kawada, Ayako Mitsuma, Tsuneo Imai |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Potassium Channels Cyclophosphamide Genotype medicine.medical_treatment Breast Neoplasms QT interval Polymerase Chain Reaction Polymorphism Single Nucleotide Electrocardiography Young Adult Breast cancer Internal medicine Antineoplastic Combined Chemotherapy Protocols Medicine Humans cardiovascular diseases Prospective Studies Prospective cohort study Aged Chemotherapy business.industry Corrected qt Arrhythmias Cardiac Heart Hematology Middle Aged medicine.disease Oncology Fluorouracil Chemotherapy Adjuvant Anesthesia cardiovascular system Cardiology Female business circulatory and respiratory physiology medicine.drug Epirubicin |
| Zdroj: | Annals of oncology : official journal of the European Society for Medical Oncology. 23(3) |
| ISSN: | 1569-8041 |
| Popis: | Corrected QT (QTc) interval prolongation can induce fatal arrhythmias such as torsade de pointes.To assess the characteristics of QTc intervals and arrhythmias in women with early breast cancer who received FEC100 adjuvant chemotherapy, electrocardiograms (ECGs) were recorded before and after each chemotherapy. Associations between QTc interval prolongation and single nucleotide polymorphisms (SNPs) of potassium channel genes were also investigated.A total of 131 ECG records were obtained in 34 patients who received 153 cycles of FEC100. QTc intervals could be measured in 127 records. There was a significant trend toward QTc interval prolongation after each treatment, persisting through four cycles of chemotherapy (P0.001). Median QTc interval prolongations were 13, 11, 18, and 14 ms in the first through fourth cycles of chemotherapy, respectively. QTc intervals differed significantly between cycles 1 and 4 before treatment as well as after treatment (P0.05). A single supraventricular premature contraction was noted in 3 (2.3%) of the 131 cycles in 2 (5.9%) of the 34 patients. There was no significant association between QTc interval prolongation and SNPs of potassium channel genes.This prospective study confirmed that FEC100 is associated with significant QTc interval prolongation in women with early breast cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|