Distribution of diandric and digynic triploidy depending on gestational age
| Autor: | Anna Kucińska-Chahwan, Julia Bijok, Grzegorz Panek, Diana Massalska, Janusz Zimowski, Tomasz Roszkowski, Katarzyna Ozdarska |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Gestational Age Biology Spontaneous pregnancy Pregnancy Second trimester Digynic (maternal) triploidy Gestational Weeks Genetics medicine Humans Prospective Studies Genetics (clinical) Obstetrics Obstetrics and Gynecology Gestational age General Medicine medicine.disease Triploidy QF-PCR Abortion Spontaneous Pregnancy Trimester First First trimester Reproductive Medicine Pregnancy Trimester Second Diandric (paternal) triploidy Female Poland MS-MLPA Developmental Biology |
| Zdroj: | Journal of Assisted Reproduction and Genetics |
| ISSN: | 1573-7330 1058-0468 |
| DOI: | 10.1007/s10815-021-02202-4 |
| Popis: | Purpose To establish the distribution of diandric and digynic triploidy depending on gestational age. Methods 107 triploid samples tested prospectively in a single genetic department during a four-year period were analyzed for parental origin of triploidy by Quantitative Fluorescent Polymerase Chain Reaction (QF-PCR) (n=95) with the use of matching parental samples or by MS-MLPA (n=12), when parental samples were unavailable. Tested pregnancies were divided into three subgroups with regard to the gestational age at spontaneous pregnancy loss: 14 gestational weeks. Results Diandric triploidy constituted overall 44.9% (46.5% in samples miscarried 14 gestational weeks). Conclusions The distribution of diandric and digynic triploidy depends on gestational age. The majority of diandric triploid pregnancies is lost in the first trimester of pregnancy. In the second trimester, diandric cases are at least twice less frequent than digynic ones. |
| Databáze: | OpenAIRE |
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