The Ameliorative Effects of Saikosaponin in Thioacetamide-Induced Liver Injury and Non-Alcoholic Fatty Liver Disease in Mice

Autor: Wei-Li Lin, Huei-Jyuan Liao, Geng-Ruei Chang, Tzu-Chun Lin, Yu-Wen Lu
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
FGF21
QH301-705.5
thioacetamide
Pharmacology
Catalysis
Article
Inorganic Chemistry
Superoxide dismutase
chemistry.chemical_compound
Mice
Non-alcoholic Fatty Liver Disease
medicine
Animals
Aspartate Aminotransferases
Physical and Theoretical Chemistry
Oleanolic Acid
Biology (General)
Molecular Biology
QD1-999
Spectroscopy
Liver injury
chemistry.chemical_classification
biology
Superoxide Dismutase
Glutathione peroxidase
Organic Chemistry
Fatty liver
Anti-Inflammatory Agents
Non-Steroidal
Alanine Transaminase
General Medicine
Saponins
medicine.disease
Catalase
Computer Science Applications
Sterol regulatory element-binding protein
Mice
Inbred C57BL
saikosaponin-d
Chemistry
chemistry
inflammation
biology.protein
Alkaline phosphatase
fatty liver disease
Thioacetamide
Chemical and Drug Induced Liver Injury
liver injury
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 11383, p 11383 (2021)
Volume 22
Issue 21
ISSN: 1422-0067
Popis: Liver disorders are a major health concern. Saikosaponin-d (SSd) is an effective active ingredient extracted from Bupleurum falcatum, a traditional Chinese medicinal plant, with anti-inflammatory and antioxidant properties. However, its hepatoprotective properties and underlying mechanisms are unknown. We investigated the effects and underlying mechanisms of SSd treatment for thioacetamide (TAA)-induced liver injury and high-fat-diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) in male C57BL/6 mice. The SSd group showed significantly higher food intake, body weight, and hepatic antioxidative enzymes (catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD)) and lower hepatic cyclooxygenase-2 (COX-2), serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and fibroblast growth factor-21 (FGF21) compared with controls, as well as reduced expression of inflammation-related genes (nuclear factor kappa B (NF-κB) and inducible nitric oxide synthase (iNOS)) messenger RNA (mRNA). In NAFLD mice, SSd reduced serum ALT, AST, triglycerides, fatty acid–binding protein 4 (FABP4) and sterol regulatory element–binding protein 1 (SREBP1) mRNA, and endoplasmic reticulum (ER)-stress-related proteins (phosphorylated eukaryotic initiation factor 2α subunit (p-eIF2α), activating transcription factor 4 (ATF4), and C/EBP homologous protein (CHOP). SSd has a hepatoprotective effect in liver injury by suppressing inflammatory responses and acting as an antioxidant.
Databáze: OpenAIRE
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