Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3
| Autor: | Cuifang Hao, Xiaoyan Liang, Lin He, Han Zhao, Xuan Gao, Li You, Jin-e Xu, Dongni Zhao, Yuhua Shi, Chun-e Ren, Yingying Qin, Wei Zhang, Zhiqiang Li, Dongyi Zhu, Jinlong Ma, Junli Zhao, Xiaoming Zhao, Yueran Zhao, Zi-Jiang Chen, Yongyong Shi, Ling Geng, Shi-Ling Chen, Yingpu Sun, Junhao Yan, Xiuqin Sun, Aijun Yang, Bo Zhang, Yuehong Bian, Yiran Li, Jiayin Liu, Junzhao Zhao, Yuan Li, Hong Jiang, Yajie Zhang |
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| Rok vydání: | 2010 |
| Předmět: |
Genetics
Genotype Genome Human Chromosome Mapping Chromosome Genome-wide association study Locus (genetics) Single-nucleotide polymorphism Biology Polycystic ovary Genome Asian People Meta-Analysis as Topic Gene mapping Chromosomes Human Pair 2 Odds Ratio Humans Female Genetic Predisposition to Disease Chromosomes Human Pair 9 Gene Genome-Wide Association Study Polycystic Ovary Syndrome |
| Zdroj: | Nature Genetics. 43:55-59 |
| ISSN: | 1546-1718 1061-4036 |
| DOI: | 10.1038/ng.732 |
| Popis: | Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women. To identify causative genes, we conducted a genome-wide association study (GWAS) of PCOS in Han Chinese. The discovery set included 744 PCOS cases and 895 controls; subsequent replications involved two independent cohorts (2,840 PCOS cases and 5,012 controls from northern Han Chinese; 498 cases and 780 controls from southern and central Han Chinese). We identified strong evidence of associations between PCOS and three loci: 2p16.3 (rs13405728; combined P-value by meta-analysis P(meta) = 7.55 × 10⁻²¹, odds ratio (OR) 0.71); 2p21 (rs13429458, P(meta) = 1.73 × 10⁻²³, OR 0.67); and 9q33.3 (rs2479106, P(meta) = 8.12 × 10⁻¹⁹, OR 1.34). These findings provide new insight into the pathogenesis of PCOS. Follow-up studies of the candidate genes in these regions are recommended. |
| Databáze: | OpenAIRE |
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