Porokeratosis of Mibelli: benzylhydrochlorothiazide-induced new lesions accompanied by eosinophilic spongiosis
| Autor: | Kinuyo Nakamura, Tomoo Watanabe, Nobuko Inamoto |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
Lichenoid drug eruption medicine.medical_specialty Pathology Dermatology Eosinophilia medicine Humans Aged Skin business.industry Keratosis medicine.disease Drug eruption Hydrochlorothiazide Hypertension Drug Eruptions medicine.symptom Eosinophilic spongiosis Skin lesion business Porokeratosis Spongiosis Cornoid lamella |
| Zdroj: | Journal of the American Academy of Dermatology. 11(2 Pt 2) |
| ISSN: | 0190-9622 |
| Popis: | We observed the course of development of porokeratosis stimulated by benzylhydrochlorothiazide (BHCTh) in normal-appearing skin of a patient with long-standing stable porokeratosis of Mibelli. A 72-year-old Japanese man had had porokeratosis of Mibelli for more than 50 years. During administration of BHCTh for 1 year because of his hypertension, a lichenoid drug eruption developed over the lesions of porokeratosis on the flexor aspects of his legs. Readministration of BHCTh by another, physician for 6 months resulted in the occurrence of a similar drug eruption that converted into typical skin lesions of porokeratosis 8 weeks later. Serial microscopic examination suggested that BHCTh administration resulted in eosinophilic spongiosis and cornoid lamella formation, which developed into epidermal changes characteristic of porokeratosis. |
| Databáze: | OpenAIRE |
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