In SituChelation of Ca2+in Intracellular Stores Induces Capacitative Ca2+Entry in Bovine Adrenal Chromaffin Cells

Autor:	David Powis, Mariann Zerbes
Rok vydání:	2002
Předmět:	In situ medicine.medical_specialty SERCA Chromaffin Cells Calcium-Transporting ATPases General Biochemistry Genetics and Molecular Biology Sarcoplasmic Reticulum Calcium-Transporting ATPases History and Philosophy of Science Internal medicine medicine Animals Chelation Bovine adrenal Ca2 entry Chelating Agents Dose-Response Relationship Drug Chemistry General Neuroscience Ethylenediamines Endocrinology Cytosolic ca Second messenger system Biophysics Calcium Cattle Intracellular
Zdroj:	Annals of the New York Academy of Sciences. 971:150-152
ISSN:	1749-6632 0077-8923
Popis:	Reduction of intracellular Ca(2+) stores (by chelation with the EDTA structural analogue, TPEN) is itself a sufficient trigger of capacitative Ca(2+) entry. TPEN may be a useful tool in studies to investigate the mechanism of capacitative Ca(2+) entry, since potential confounders, such as changes in cytosolic Ca(2+) and second messenger levels, are obviated and the use of pharmacological modifiers of SERCA pumps and Ca(2+) release channels is avoided.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb3e64f0fe89a50d590ce4c3fd19099 https://doi.org/10.1111/j.1749-6632.2002.tb04452.x Zobrazit plný text záznamu Plný text