Comparison of antihypertensive therapies by noninvasive techniques
| Autor: | William F. Graettinger, Michael A. Weber, Russell C. Klein, Deanna G. Cheung, Jodi L. Lipson |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty Ambulatory blood pressure Time Factors Angiotensin-Converting Enzyme Inhibitors Critical Care and Intensive Care Medicine Essential hypertension Enalapril Lisinopril Internal medicine medicine Humans Aged Monitoring Physiologic biology business.industry Angiotensin-converting enzyme Blood Pressure Determination Middle Aged medicine.disease Atenolol Endocrinology Blood pressure Echocardiography Decreased blood pressure Hypertension biology.protein Aortic pressure Cardiology Cardiology and Cardiovascular Medicine business circulatory and respiratory physiology medicine.drug |
| Zdroj: | Chest. 96(1) |
| ISSN: | 0012-3692 |
| Popis: | We compared the antihypertensive effects of the beta-blocker atenolol and the converting enzyme inhibitor lisinopril during 12 weeks of treatment in patients with mild to moderate essential hypertension. Atenolol (n = 10) significantly decreased conventionally measured blood pressure from 144/103 to 135/93 mm Hg and lisinopril (n = 9) from 150/104 to 130/92 mm Hg. Based on data derived from automated 24-h ambulatory blood pressure monitoring, atenolol decreased the average whole-day systolic pressure by 18 +/- 6 mm Hg (p less than 0.02) and the diastolic pressure by 11 +/- 2 mm Hg (p less than 0.01). Lisinopril produced decreases of 27 +/- 5 mm Hg (p less than 0.01) and 13 +/- 2 mm Hg (p less than 0.001). Examination of the 24-h blood pressure patterns showed that the efficacies of the two drugs were similar. Each appeared to be effective throughout the whole-day monitoring period, although only lisinopril significantly decreased blood pressure during the final four-h period (4 AM to 8 AM) preceding the next day's dose. Neither drug produced significant echocardiographic changes in left ventricular wall thickness or muscle mass during the short-term treatment. Lisinopril and atenolol effectively decrease blood pressure during a 24-h period. Moreover, we found that automated whole-day blood pressure monitoring is a useful tool for comparing the efficacy and duration of action of differing antihypertensive agents. |
| Databáze: | OpenAIRE |
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