Incidence of Celiac Disease in Down Syndrome: A Longitudinal, Population-Based Birth Cohort Study
| Autor: | Kathryn K. Ostermaier, Slavica K. Katusic, Amy L. Weaver, Robert G. Voigt, Ruth E. Stoeckel, Scott M. Myers |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Down syndrome Adolescent Health Status Minnesota Population Disease Article Serology Cohort Studies Young Adult 03 medical and health sciences Age Distribution 0302 clinical medicine Risk Factors 030225 pediatrics medicine Humans Longitudinal Studies Child education education.field_of_study business.industry Incidence Incidence (epidemiology) Infant medicine.disease Confidence interval Celiac Disease Child Preschool Pediatrics Perinatology and Child Health Female 030211 gastroenterology & hepatology Diagnosis code Down Syndrome Birth cohort business |
| Zdroj: | Clin Pediatr (Phila) |
| ISSN: | 1938-2707 0009-9228 |
| DOI: | 10.1177/0009922820941247 |
| Popis: | American Academy of Pediatrics (AAP) guidelines for children with Down syndrome (DS) include assessment for celiac disease (CD), although data to support this recommendation have been inconsistent. We determined the incidence of CD among children with DS in a population-based birth cohort of children born from 1976 to 2000 in Olmsted County, Minnesota. Individuals with karyotype-confirmed DS and CD (using diagnosis codes, positive serology, and duodenal biopsies) were identified. The incidence of CD in DS was compared with the published incidence of CD for Olmsted County residents (17.4 [95% confidence interval = 15.2-19.6] per 100 000 person-years). Among 45 individuals with DS from the birth cohort, 3 (6.7%) were identified with positive celiac serology and confirmatory biopsies at ages 9, 12, and 23 years, for an incidence of 325 per 100 000 person-years. Thus, individuals with DS have more than 18 times the incidence rate of CD compared with the general population, supporting the AAP guidelines. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|