Levels of Breast Milk PBDEs From Southern Taiwan and Their Potential Impact on Neurodevelopment
Autor: | Huei Lin Huang, How-Ran Chao, Gou Ping Chang-Chien, Tsui-Chun Tsou |
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Rok vydání: | 2011 |
Předmět: |
Pediatrics
medicine.medical_specialty Southern taiwan Taiwan Physiology Biology Breast milk Language Development Bayley Scales of Infant Development Gas Chromatography-Mass Spectrometry Cognition Polybrominated diphenyl ethers Adaptation Psychological Post-hoc analysis Halogenated Diphenyl Ethers medicine Humans Developmental neurotoxicity Potential impact Milk Human Infant Stepwise regression Pediatrics Perinatology and Child Health Linear Models Environmental Pollutants Female Psychomotor Performance |
Zdroj: | Pediatric Research. 70:596-600 |
ISSN: | 1530-0447 0031-3998 |
Popis: | In vivo studies have demonstrated that prenatal or neonatal exposure to polybrominated diphenyl ethers (PBDEs) causes developmental neurotoxicity. However, there is a lack of human data. Our hypothesis was that PBDEs would result in lower infant neurodevelopment scores. This is a post hoc analysis of previous studies. Fourteen PBDEs in 70 breast milk were analyzed using a high-resolution gas chromatograph/high-resolution mass spectrometer. Infant neurodevelopment at the age of 8-12 mo was determined using the Bayley Scales of Infants and Toddlers Development, third edition (Bayley-III). The median of Σ14 PBDEs (the sum of 14 PBDE congeners) was 2.92 ng/g lipid. The Σ14 PBDE concentrations were not correlated with Bayley-III scores on cognitive, language, motor, social-emotional, or adaptive behavior scales. A significantly inverse association between brominated diphenyl ether (BDE)-209 and the cognitive scale was found after multivariate stepwise linear regression analyses (B = -0.007, adjusted R = -0.224, p = 0.032). In contrast, the language scale was positively correlated with BDE-196 (B = 0.096, adjusted R = 0.315, p = 0.002). Our results are consistent with most in vivo studies, suggesting that prenatal or postnatal exposure to BDE-209 potentially delays the neurological development. |
Databáze: | OpenAIRE |
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