Could local surgery improve survival in de novo stage IV breast cancer?
Autor: | Xing Li, Guangzheng Deng, Zeyu Shuang, Zhenchong Xiong, Xinhua Xie, Jin Wang, Xi Wang |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Adult Cancer Research medicine.medical_specialty Soft tissue metastasis Biopsy Population Local surgery Breast Neoplasms Kaplan-Meier Estimate Mastectomy Segmental lcsh:RC254-282 Metastasis 03 medical and health sciences 0302 clinical medicine Breast cancer Surgical oncology Genetics medicine Humans Neoplasm Metastasis education Survival analysis Aged Neoplasm Staging Proportional Hazards Models Retrospective Studies education.field_of_study De novo stage IV business.industry Bone metastasis Middle Aged medicine.disease Prognosis lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Metastatic breast cancer Primary tumor Surgery Primary tumor size 030104 developmental biology Treatment Outcome Oncology 030220 oncology & carcinogenesis Female business Research Article |
Zdroj: | BMC Cancer, Vol 18, Iss 1, Pp 1-9 (2018) BMC Cancer |
ISSN: | 1471-2407 |
Popis: | Background Resection of the primary tumor is recommended for symptom relief in de novo stage IV breast cancer. We explored whether local surgery could provide a survival benefit in these patients and attempted to characterize the population that could benefit from surgery. Methods Metastatic Breast cancer patients (N = 313) with intact primary tumor between January 2006 and April 2013 were separated into two groups according to whether or not they had undergone surgery. The difference in characteristics between the two groups was analyzed using chi-square test, Fisher’s exact test and Mann-Whitney test. Univariable and multivariable Cox regression and stratified survival analysis were used to assess the effect of surgery on survival. Results Of the 313 patients, 188 (60.1%) underwent local surgery. Patients with local surgery had a 47% reduction in mortality risk vs. those with no surgery (median survival 78 months vs. 37 months; HR = 0.53; 95% CI, 0.36–0.78) after adjustment for clinical and tumor characteristics. Stratified survival analysis showed that patients with bone metastasis alone (and primary tumor ≤5 cm), soft tissue metastasis, or ≤ 3 metastasis sites benefit from surgery. Conclusion Surgical resection of the primary tumor can improve survival in selected de novo stage IV breast cancer patients. |
Databáze: | OpenAIRE |
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