Second-trimester angiogenic factors as biomarkers for future-onset preeclampsia
| Autor: | E. Ramsey Unal, Donna D. Johnson, Eugene Y. Chang, Christopher J. Robinson |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
medicine.medical_specialty Angiogenesis Pregnancy Proteins Preeclampsia Pre-Eclampsia Pregnancy Internal medicine medicine Humans Tyrosine reproductive and urinary physiology Placenta Growth Factor Vascular Endothelial Growth Factor Receptor-1 business.industry Obstetrics and Gynecology Liter medicine.disease Endocrinology Pregnancy Trimester Second Hypertension embryonic structures Gestation Angiogenesis Inducing Agents Female Age of onset business Biomarkers Soluble fms-like tyrosine kinase-1 |
| Zdroj: | American Journal of Obstetrics and Gynecology. 197:211.e1-211.e4 |
| ISSN: | 0002-9378 |
| Popis: | Objective The purpose of this study was to determine whether second-trimester soluble fms-like tyrosine kinase-1 and placenta growth factor (PlGF) are altered in patients who have preeclampsia develop compared with controls. Furthermore, soluble fms-like tyrosine kinase-1 and placenta growth factor levels in patients with chronic hypertension are described. Study Design With the use of a research database, 21 patients who had severe preeclampsia develop, 34 controls, and 9 patients with chronic hypertension were enrolled. Placenta growth factor and soluble fms-like tyrosine kinase-1 serum levels were determined by enzyme-linked immunosorbent assay. Appropriate statistical tests were used and results were reported as median (quartile 1-quartile 3) in picograms per milliliter. Results Placenta growth factor was significantly lower in patients in the second trimester who later had severe preeclampsia develop but soluble fms-like tyrosine kinase-1 was unchanged compared with healthy pregnancies. In patients with chronic hypertension, placenta growth factor and soluble fms-like tyrosine kinase-1 levels were not different compared with controls. Conclusion Second-trimester placenta growth factor levels are altered in patients who had severe preeclampsia develop. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect