Effects of Chlamydia trachomatis infection on the expression of natural killer (NK) cell ligands and susceptibility to NK cell lysis
| Autor: | A. J. Carmichael, J. S. H. Gaston, Jane C. Goodall, C. E. Hook, Mark R. Wills, Veronique M. Braud, Natasha Telyatnikova |
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| Rok vydání: | 2004 |
| Předmět: |
Immunology
Chlamydia trachomatis Ligands Major histocompatibility complex Cell Line Natural killer cell Microbiology Major Histocompatibility Complex Interferon-gamma 03 medical and health sciences Interleukin 21 0302 clinical medicine Immune system Bacterial Proteins Interferon medicine Humans Immunology and Allergy Receptors Immunologic 030304 developmental biology 0303 health sciences Lymphokine-activated killer cell biology Janus kinase 3 Epithelial Cells Original Articles Chlamydia Infections 3. Good health Killer Cells Natural medicine.anatomical_structure Leukocytes Mononuclear Interleukin 12 biology.protein K562 Cells HeLa Cells 030215 immunology medicine.drug |
| Zdroj: | Clinical and Experimental Immunology. 138:54-60 |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1111/j.1365-2249.2004.02596.x |
| Popis: | SUMMARY Natural killer (NK) cells are an important component of the immediate immune response to infections, including infection by intracellular bacteria. We have investigated recognition of Chlamydia trachomatis (CT) by NK cells and show that these cells are activated to produce interferon (IFN)-γ when peripheral blood mononuclear cells (PBMC) are stimulated with CT organisms. Furthermore, infection of epithelial cell lines with CT renders them susceptible to lysis by human NK cells. Susceptibility was observed 18–24 h following infection and required protein synthesis by the infecting chlamydiae, but not by the host cell; heat or UV inactivated chlamydiae did not induce susceptibility to NK cell lysis. CT infection was also shown to decrease the expression of classical and non-classical major histocompatibility complex (MHC) molecules on infected cells, thus allowing recognition by NK cells when combined with an activating signal. A candidate activating signal is MICA/B, which was shown to be expressed constitutively on epithelial cells. |
| Databáze: | OpenAIRE |
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