Discovery and function exploration of microRNA-155 as a molecular biomarker for early detection of breast cancer
| Autor: | Yikun Jiang, Qingyu Chang, Hairong Qian, Xuemin Liu, Haiqiang Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Early detection Breast Neoplasms Breast cancer Surgical oncology Internal medicine Diagnosis microRNA Biomarkers Tumor medicine Humans Pharmacology (medical) Radiology Nuclear Medicine and imaging Protein Interaction Maps business.industry Biomarker General Medicine Middle Aged medicine.disease Molecular biomarkers Gene Expression Regulation Neoplastic MicroRNAs Area Under Curve Ppi network Biomarker (medicine) Original Article Female business MicroRNA-155 Function (biology) |
| Zdroj: | Breast Cancer (Tokyo, Japan) |
| ISSN: | 1880-4233 1340-6868 |
| DOI: | 10.1007/s12282-021-01215-2 |
| Popis: | Background MicroRNA-155 (miR-155) may function as a diagnostic biomarker of breast cancer (BC). Nevertheless, the available evidence is controversial. Therefore, we performed this study to summarize the global predicting role of miR-155 for early detection of BC and preliminarily explore the functional roles of miR-155 in BC. Methods We first collected published studies and applied the bivariate meta-analysis model to generate the pooled diagnostic parameters of miR-155 in diagnosing BC such as sensitivity, specificity and area under curve (AUC). Then, we applied function enrichment and protein–protein interactions (PPI) analyses to explore the potential mechanisms of miR-155. Results A total of 21 studies were finally included. The results indicated that miR-155 allowed for the discrimination between BC patients and healthy controls with a sensitivity of 0.87 (95% CI 0.78–0.93), specificity of 0.82 (0.72–0.89), and AUC of 0.91 (0.88–0.93). In addition, the overall sensitivity, specificity and AUC for circulating miR-155 were 0.88 (0.76–0.95), 0.83 (0.72–0.90), and 0.92 (0.89–0.94), respectively. Function enrichment analysis revealed several vital ontologies terms and pathways associated with BC occurrence and development. Furthermore, in the PPI network, ten hub genes and two significant modules were identified to be involved in some important pathways associated with the pathogenesis of BC. Conclusions We demonstrated that miR-155 has great potential to facilitate accurate BC detection and may serve as a promising diagnostic biomarker for BC. However, well-designed cohort studies and biological experiments should be implemented to confirm the diagnostic value of miR-155 before it can be applied to routine clinical procedures. |
| Databáze: | OpenAIRE |
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