Prevalence of genetic risk factors for coronary artery disease in Corsica island (France)
| Autor: | Laurianne Giovannoni, Giuseppe Vona, C. M. Calò, Laurent Varesi, Alessandra Falchi, Ignazio S. Piras, Pedro Moral |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Clinical Biochemistry Population Gene Dosage Coronary Artery Disease Pathology and Forensic Medicine Risk Factors Internal medicine Integrin complex Genotype medicine Humans Genetic Predisposition to Disease education Molecular Biology Allele frequency Genetics education.field_of_study Polymorphism Genetic biology Angiotensin-converting enzyme Odds ratio Middle Aged Endocrinology Methylenetetrahydrofolate reductase biology.protein Female France Restriction fragment length polymorphism Biomarkers |
| Zdroj: | Experimental and Molecular Pathology. 79:210-213 |
| ISSN: | 0014-4800 |
| DOI: | 10.1016/j.yexmp.2005.09.005 |
| Popis: | We have investigated the frequencies of seven markers among 100 unrelated individuals with angiographically documented CAD (Coronary Artery Disease) and among 100 unrelated healthy blood donors in the central region of Corsica island (France). The seven polymorphisms analyzed were chosen from six candidate genes involved in (1) Renin–Angiotensin system: Angiotensin converting enzyme (ACE I/D), (2) Lipid metabolism: Cholesterol Ester Transfer Protein gene (CETP TAQ1B), (3) Platelet aggregation: alpha and beta subunits of the platelet GpIIb/GpIIIa integrin complex (GpIIb HPA3 and GpIIIa Pl A1/A2 ), (4) Coagulation fibrinolysis: Plasminogen Activator Tissue (PLAT TPA25 I/D) and Methylenetetrahydrofolate Reductase (MTHFR C677T and A1298C). The samples were genotyped using the polymerase chain reaction followed by restriction enzyme analysis for the RFLPs. No significant difference in allele frequencies between patient and control groups was observed. The occurrence of the MTHFR T677T genotype and of the T677T/A1298A compound genotype is higher in cases (20%) than in the controls (4%). Odds ratio seems to indicate that individuals with the MTHFR T677T genotype and the T677T/A1298A compound genotype had a 6-fold increased risk for developing CAD (ORs = 6; 95% CIs = 1.96–18.28) suggesting a possible association of MTHFR C677T with the risk of CAD in Corsican population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect