Correction to: Stem cell membrane-coated isotretinoin for acne treatment
| Autor: | Mingji Zhu, Jeung-Hoon Lee, Shiyi Wang, Fuqiang Zhang, Tianqi Meng, Ri-Hua Jiang, Yongri Jin, Jing Li, Jinlan Jiang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
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medicine.medical_specialty Skin Absorption Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) Bioengineering Administration Cutaneous Applied Microbiology and Biotechnology Acne Vulgaris Medical technology medicine Human Umbilical Vein Endothelial Cells Animals Humans R855-855.5 Isotretinoin Skin Drug Carriers Mesocricetus business.industry Stem Cells Cell Membrane Correction Acne treatment Molecular medicine Dermatology Disease Models Animal Molecular Medicine Nanoparticles Dermatologic Agents Rabbits Stem cell business TP248.13-248.65 Biotechnology medicine.drug |
| Zdroj: | Journal of Nanobiotechnology Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-3 (2021) |
| ISSN: | 1477-3155 |
| Popis: | Topical isotretinoin is commonly used to treat acne. However, topical isotretinoin has side effects and can hardly permeate through the stratum corneum, the most important skin barrier. Therefore, this study aimed to demonstrate the efficacy of nanoparticles as stable carriers with great curative effects, low side effects, and strong transdermal ability.In a rabbit model of hyperkeratinization, STCM-ATRA-NPs showed significant therapeutic efficacy. By contrast, negative therapeutic efficacy was observed in a golden hamster model of hyper sebum production. Scanning electron microscopy and Fourier transform infrared spectral analyses showed that nanoparticles could penetrate the stratum corneum. Western blotting demonstrated that the nanoparticles could enhance the transdermal efficacy of isotretinoin by reducing the effect of keratin and tight junction proteins. Further, nanoparticles enhanced endocytosis, thereby promoting drug penetration and absorption into the skin.STCM-ATRA-NPs were demonstrated to control isotretinoin release, reducing its side effects, and efficiently permeating through the skin by reducing the effect of keratin and tight junction proteins and enhancing endocytosis. |
| Databáze: | OpenAIRE |
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