Metastatic Brain Choriocarcinoma in a Postmenopausal Woman: A Case Report
| Autor: | Tania Aftandilians, Shirley Wong, Inessa Dombrovsky, Robert J Stowe, Hannah R Tilden |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pregnancy test
medicine.medical_specialty Abnormal Pregnancy Disease 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Antineoplastic Combined Chemotherapy Protocols Medicine Humans Choriocarcinoma Neoplasm Metastasis Cyclophosphamide reproductive and urinary physiology Aged Etoposide business.industry Gestational trophoblastic disease Obstetrics Brain Neoplasms Brain Mass General Medicine Articles medicine.disease Primary tumor female genital diseases and pregnancy complications Postmenopause Methotrexate Vincristine 030220 oncology & carcinogenesis embryonic structures Uterine Neoplasms Dactinomycin Female Neurosurgery business |
| Zdroj: | The American Journal of Case Reports |
| ISSN: | 1941-5923 |
| Popis: | Patient: Female, 66-year-old Final Diagnosis: Choriocarcinoma Symptoms: Vaginal bleeding Medication: — Clinical Procedure: — Specialty: Obstetrics and Gynecology Objective: Unusual clinical course Background: Choriocarcinoma is the most aggressive form of gestational trophoblastic disease and usually occurs in women of childbearing age, most commonly within 1 year after an abnormal pregnancy. Postmenopausal chorio-carcinoma is exceptionally rare and few cases have been described in the literature. Case Report: We present the case of a 66-year-old woman who presented to the Emergency Department with sudden onset of left upper- and lower-extremity weakness. She was found to have a brain mass, which was excised by neurosurgery and found to be a choriocarcinoma. She was then started on standard first-line therapy of EMACO, but was subsequently lost to follow-up. Conclusions: Postmenopausal choriocarcinoma is rare and there are few case reports in the literature. It is a rare but possibly under-diagnosed metastatic disease in women. At present, a postmenopausal woman without a clear primary tumor should have a pregnancy test performed to rule out choriocarcinoma, as it is readily responsive to therapy. |
| Databáze: | OpenAIRE |
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