Fatty liver--based identification of two distinct hypertriglyceridemic subgroups in familial combined hyperlipidemia
| Autor: | Martijn C. G. J. Brouwers, Tjerk W.A. de Bruin, Coen D.A. Stehouwer, Carla J.H. van der Kallen, Margee G. Robertus-Teunissen, Monique A.L. Bilderbeek-Beckers, Marleen M.J. van Greevenbroek |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Very low-density lipoprotein Apolipoprotein B Endocrinology Diabetes and Metabolism medicine.medical_treatment Population Hyperlipidemia Familial Combined Adipose tissue Lipoproteins VLDL Body Mass Index chemistry.chemical_compound Endocrinology Internal medicine medicine Humans Ultrasonography Hypertriglyceridemia biology Anthropometry Cholesterol Insulin Fatty liver Alanine Transaminase Middle Aged medicine.disease Fatty Liver Phenotype chemistry Adipose Tissue Liver biology.protein Female Body mass index Lipoprotein |
| Zdroj: | Metabolism: clinical and experimental. 56(10) |
| ISSN: | 0026-0495 |
| Popis: | The present study was conducted to investigate whether the fatty liver phenotype could be helpful in the identification of subgroups with distinct metabolic properties and lipid profiles within familial combined hyperlipidemia (FCHL). One hundred eighty-five FCHL family members participated in the current study; 38 subjects were found to be hypertriglyceridemic, of whom 66% showed evidence of fatty liver as measured with ultrasound. A detailed comparison between the hypertriglyceridemic FCHL subjects with (n = 25) and without (n = 13) fatty liver revealed that, despite very similar plasma triglyceride levels (3.5 vs 3.2 mmol/L in subjects with and without fatty liver, respectively), the fatty liver subgroup presented with significantly higher body mass index, visceral adipose tissue (ultrasound), insulin, and alanine aminotransferase levels. Moreover, very low-density lipoprotein (VLDL) subclass analysis showed that the VLDL2 fraction of the fatty liver subgroup contained significantly less cholesterol and triglycerides (P = .02 for both parameters), which was likely explained by a decreased VLDL2 particle number because VLDL2 apolipoprotein B levels tended to be lower (P = .08). These data indicate that hypertriglyceridemic FCHL subjects may belong to metabolically distinct subgroups and suggest that a refinement of the hypertriglyceridemic FCHL phenotype by adding information on fatty liver will eventually facilitate the elucidation of its complex genetic background. |
| Databáze: | OpenAIRE |
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