Osteogenic effect of fluvastatin combined with biodegradable gelatin-hydrogel
| Autor: | Hideki Nomoto, Masao Yoshinari, Naoto Okumori, Koji Tanabe, Tadashi Miura |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Scaffold Materials science food.ingredient X-ray microtomography Bone Regeneration Indoles Calvaria Gelatin Fatty Acids Monounsaturated Rats Sprague-Dawley Random Allocation food Osteogenesis Absorbable Implants medicine Animals Bone regeneration Fluvastatin General Dentistry Tissue Scaffolds Skull Water Hydrogels X-Ray Microtomography Rats medicine.anatomical_structure Self-healing hydrogels Ceramics and Composites Ultraviolet irradiation Hydroxymethylglutaryl-CoA Reductase Inhibitors medicine.drug Biomedical engineering |
| Zdroj: | Dental materials journal. 31(3):489-493 |
| Popis: | The aim was to investigate the local osteogenic effect of fluvastatin incorporated into a biodegradable gelatin-hydrogel (GH) scaffold. The GH scaffolds were prepared through crosslinking by ultraviolet irradiation followed by freeze-drying. Two circular defects were surgically created on fifteen-week-old male rats calvaria. All defects of each rat were randomly filled with two of three treatments, specifically: fluvastatin incorporated into a GH disk (Flu-GH), distilled water incorporated into a GH disk, and no treatment. New bone formation was quantitatively analyzed after 7, 14, and 28 days using a micro-computed tomography (micro-CT) system, and histologically observed. Evaluation by micro-CT revealed a significant difference in new bone formation among the three kinds of defect. A highly osteogenic effect was observed in the Flu-GH group. The results showed that the fluvastatin incorporated into a biodegradable GH scaffold promoted osteogenesis in rat calvarial bone, indicating its potential for bone regeneration. |
| Databáze: | OpenAIRE |
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