Impact of nutritional and inflammatory status in patients with critical limb-threatening ischemia
| Autor: | Noelia Cenizo-Revuelta, Elena García-Rivera, Álvaro Revilla-Calavia, C. Vaquero-Puerta, Liliana Fidalgo-Domingos, M. Martín-Pedrosa, Enrique M. San Norberto, Isabel Estévez-Fernández |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Nutritional biomarkers Neutrophils Arterial disease business.industry Lymphocyte Ischemia Nutritional status Retrospective cohort study Prognosis medicine.disease Gastroenterology Inflammatory biomarkers Nutrition Assessment medicine.anatomical_structure Internal medicine medicine Humans In patient Lymphocytes Cardiology and Cardiovascular Medicine business Retrospective Studies |
| Zdroj: | International Angiology. 40 |
| ISSN: | 1827-1839 0392-9590 |
| DOI: | 10.23736/s0392-9590.21.04739-8 |
| Popis: | BACKGROUND A pro-inflammatory state and a poor nutritional status have been associated with severity and prognosis of patients with peripheral arterial disease (PAD). The clinical applicability of the different pre-operative nutritional and inflammatory biomarkers in patients with critical limb-threatening ischemia (CLTI) was analyzed. METHODS A retrospective observational study was performed, that included all patients with CLTI revascularized from January 2016 to July 2019. The inflammatory state was calculated using neutrophil/lymphocyte (NLR), lymphocyte/monocyte (LMR) and platelet/lymphocyte ratios (PLR). For nutritional status, the Prognostic Nutritional Index (PNI) was calculated. Mortality and number of major amputations at 6 months and hospital length-of stay were studied. RESULTS 310 patients were included. Higher levels of NLR and lower levels of PNI were associated with mortality (6.61±5.6 vs. 3.98±3.27, P=0.034; 40.33±7.89 vs. 45.73±7.48, P=0.05, respectively). Lower levels of PNI and LMR (42.57±7.82 vs. 45.44±7.65, P=0.036; 2.77±1.61 vs. 3.22±1.75, P=0.013, respectively) and higher levels of NLR (6.91±7.85 vs. 3.94±2.57, P=0.023) were associated with major amputations. The mean hospital length-of-stay was higher in patients with lower levels of PNI and LMR (P=0.000 and P=0.003) and higher levels of NLR and PLR (P=0.001 and P=0.002). A PNI |
| Databáze: | OpenAIRE |
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