Adipose‐derived mesenchymal stem cells induced PAX8 promotes ovarian cancer cell growth by stabilizing TAZ protein

Autor: Meixin Liu, Jun Zhou, Chong Liu, Min Li, Chengzhan Zhu, Jing Yang, Huansheng Zhou, Fengsheng Yu, Wenqiang Luo, Yijing Chu, Qianqian Wang, Rendong Han, Yuanhua Ye, Wei Wan
Rok vydání: 2021
Předmět:
TAZ
0301 basic medicine
Mice
Nude
Adipose tissue
Apoptosis
Endogeny
Biology
Metastasis
Mice
PAX8 Transcription Factor
03 medical and health sciences
0302 clinical medicine
Cell Movement
In vivo
Biomarkers
Tumor
Tumor Cells
Cultured
medicine
Animals
Humans
Cell Proliferation
Ovarian Neoplasms
Mice
Inbred BALB C
Cell growth
Mesenchymal stem cell
Intracellular Signaling Peptides and Proteins
adipose‐derived mesenchymal stem cells
Mesenchymal Stem Cells
Original Articles
Cell Biology
medicine.disease
PAX8
Xenograft Model Antitumor Assays
Gene Expression Regulation
Neoplastic
ovarian cancer
030104 developmental biology
protein stability
Transcriptional Coactivator with PDZ-Binding Motif Proteins
030220 oncology & carcinogenesis
Cancer cell
Cancer research
Molecular Medicine
Original Article
Female
Ovarian cancer
Zdroj: Journal of Cellular and Molecular Medicine
ISSN: 1582-4934
1582-1838
Popis: Our previous studies have shown that the Adipose‐derived mesenchymal stem cells (ADSCs) can regulate metastasis and development of ovarian cancer. However, its specific mechanism has yet to be fully revealed. In this study, an RNA‐seq approach was adopted to compare the differences in mRNA levels in ovarian cancer cells being given or not given ADSCs. The mRNA level of paired box 8 (PAX8) changed significantly and was confirmed as an important factor in tumour‐inducing effect of ADSCs. In comparison with the ovarian cancer cells cultured in the common growth medium, those cultured in the medium supplemented with ADSCs showed a significant increase of the PAX8 level. Moreover, the cancer cell growth could be restricted, even in the ADSC‐treated group (P
Databáze: OpenAIRE
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