Clinical Significance of Preoperative Serum Levels of CA 125 and TAG-72 in Ovarian Carcinoma
| Autor: | Francisco J. Vizoso, Gonzalez A, Ruibal A, J L Balibrea, Vázquez J |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
0301 basic medicine Cancer Research medicine.medical_specialty Clinical Biochemistry Ovary Gastroenterology Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Antigens Neoplasm Internal medicine Ovarian carcinoma Biomarkers Tumor Carcinoma medicine Humans Clinical significance Prospective Studies Stage (cooking) Prospective cohort study Glycoproteins Ovarian Neoplasms business.industry Middle Aged Prognosis medicine.disease Well differentiated Survival Rate Serous fluid 030104 developmental biology medicine.anatomical_structure Endocrinology Oncology CA-125 Antigen 030220 oncology & carcinogenesis Female business |
| Zdroj: | The International Journal of Biological Markers. 12:112-117 |
| ISSN: | 1724-6008 |
| DOI: | 10.1177/172460089701200305 |
| Popis: | In a prospective study we evaluated in 48 patients with primary ovarian carcinoma the prognostic value of the preoperative circulating serum levels of CA 125 and TAG-72. Serum levels of CA 125 were above the cutoff level of 35 U/ml in 68% of patients, TAG-72 levels were higher than 6 U/ml in 50% of patients, while the simultaneous use of the two markers increased the sensitivity to 75%. Pretreatment CA 125 and TAG-72 levels were significantly lower (p < 0.05, for both) in patients with well differentiated tumors than in those with moderate or poor differentiation. Similarly, both marker levels were significantly higher (p < 0.001) in patients with residual disease after cytoreductive surgery than in those with no residual tumor. In addition, the CA 125 levels were also higher in initial stages (I-II) than in more advanced stages (III-IV) (p < 0.05), whereas TAG-72 levels were higher (p < 0.05) in patients with mucinous or endometrioid tumors than in those with serous carcinomas. The results further indicated that high preoperative serum levels of CA 125 and TAG-72 were associated with a shorter overall survival (p < 0.001 and p < 0.01, respectively). Finally, separate Cox multivariate analysis showed that preoperative CA 125 and TAG-72 serum levels were, after stage, the strongest factors to predict overall survival (p < 0.0001, p < 0.05 and p < 0.005, respectively) in patients with ovarian carcinoma. |
| Databáze: | OpenAIRE |
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