Subtle findings on fetal brain imaging in CMV infected pregnancies: What is the clinical significance? A retrospective analysis with outcome correlation
| Autor: | Brusilov Michael, Winsteen Adi, Malinger Gustavo, Wolman Igal, Krajden Haratz Karina, Birnbaum Roee, Ben-Sira Liat |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty 030105 genetics & heredity Ultrasonography Prenatal White matter 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Humans False Positive Reactions Cyst Clinical significance Pregnancy Complications Infectious Central Nervous System Cysts Genetics (clinical) Retrospective Studies Choroid plexus cyst 030219 obstetrics & reproductive medicine medicine.diagnostic_test Obstetrics business.industry Basal Ganglia Cerebrovascular Disease Infant Newborn Brain Obstetrics and Gynecology Retrospective cohort study Magnetic resonance imaging Prognosis medicine.disease Magnetic Resonance Imaging White Matter medicine.anatomical_structure Cytomegalovirus Infections Amniocentesis Female business Hydrocephalus |
| Zdroj: | Prenatal Diagnosis. 40:447-453 |
| ISSN: | 1097-0223 0197-3851 |
| DOI: | 10.1002/pd.5634 |
| Popis: | Objective To describe the prognosis of subtle findings on fetal brain imaging in pregnant women with primary CMV infection during pregnancy. Methods This was a retrospective study. The data included: timing of infection, amniocentesis results, imaging findings, obstetric outcome, and developmental assessment. Results For the 27 included patients, the time of infection was: periconception, first, second, third trimesters or unknown in 14.8%, 29.7%, 40.7%, 7.4%, and 7.4%, respectively. Seventy-four percent had only MRI findings; white matter hyperintense T2 signal (HT2) (51.8%), mild ventriculomegaly (18.5%), HT2 and temporal cyst (7.4%), dilated occipital horn (7.4%), Periventricular pseudo cyst (PVPC) with dilated occipital horn (3.7%), isolated PVPC (7.4%), choroid plexus cyst (3.7%). In 26% of fetuses, additional ultrasound findings were observed: Lenticulostriatal vasculopathy (LSV) (11.1%), LSV with PVPC (3.84%), isolated PVPC (3.84%), mild ventriculomegaly (3.84%), and bilateral temporal cysts (3.84%). In 66.6%, the MRI had false-positive findings (due to noninfected neonates). All children are developing normally, and one has a hearing deficit. Postnatal ultrasound (US) was normal in 21/27, with LSV in five, and a resolving subependymal cyst in one patient. Conclusion Subtle imaging findings are more common on MRI than US and the prognosis is most likely favorable. Performing amniocentesis will significantly reduce the false-positive rate. |
| Databáze: | OpenAIRE |
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