Validation of a rabbit model of irradiated bone healing: preliminary report
| Autor: | Stephan Langonnet, Jean-Christophe Béra, Aline Desoutter, Anne-Gaëlle Chaux-Bodard, Sophie Deneuve |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
genetic structures
medicine.medical_treatment lcsh:Surgery Bone healing behavioral disciplines and activities External radiotherapy 03 medical and health sciences 0302 clinical medicine Preliminary report medicine Dentistry (miscellaneous) 030212 general & internal medicine Bone mineral business.industry animal model external radiotherapy Mandible Irradiated bone 030206 dentistry lcsh:RD1-811 Radiation therapy lcsh:RK1-715 nervous system lcsh:Dentistry Rabbit model Periodontics Oral Surgery bone healing Nuclear medicine business psychological phenomena and processes |
| Zdroj: | Journal of Oral Medicine and Oral Surgery, Vol 26, Iss 2, p 24 (2020) |
| ISSN: | 2608-1326 |
| Popis: | Introduction: External radiotherapy can lead to severe bone alteration. The aim of this pilot study was to validate a model for assessment of postextractional bone healing in the irradiated rabbit mandible. Material and method: The radiation protocol consisted of 5 sessions delivering 8.5 Gy each. Surgery was performed immediately after completion of radiotherapy. Sacrifices were performed from Day 0 to Day 42. Results: The bone mineral density and the trabecular number were decreased after radiotherapy whereas trabecular separation increased. The main differences between irradiated and non-irradiated rabbits were observed at Day 28 and 42. Discussion: Radiation seems to cause a delay in bone healing. It decreases bone quality and bone mineral density. Five sessions seem to be a valuable compromise between tissues effect and feasibility of the experiment. Conclusion: This model seems to be valuable for evaluating postextractional bone healing in the irradiated rabbit mandible. |
| Databáze: | OpenAIRE |
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