Effect of hydrocortisone and interleukins 1 and 2 on eosinophil progenitors in hypereosinophilic states
| Autor: | Jacob M. Rowe, James K. Brennan, Camille N. Abboud, Jane L. Liesveld, Frank T. Slovick |
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| Rok vydání: | 1988 |
| Předmět: |
Interleukin 2
Adult Male medicine.medical_specialty Hydrocortisone medicine.medical_treatment Hypereosinophilia Biology Peripheral blood mononuclear cell Colony-Forming Units Assay Internal medicine Eosinophilia medicine Humans Monocyte Interleukin Cell Biology Eosinophil Middle Aged Eosinophils medicine.anatomical_structure Endocrinology Cytokine Immunology Interleukin-2 Female medicine.symptom medicine.drug Interleukin-1 |
| Zdroj: | International journal of cell cloning. 6(6) |
| ISSN: | 0737-1454 |
| Popis: | The growth of eosinophil progenitors (CFU-Eo) and its modulation by hydrocortisone (HC), mononuclear cells, interleukin 1 (IL-1), and interleukin 2 (IL-2) in three cases of eosinophilia are reported in this paper. One microM HC decreased the proportion of CFU-Eo in each of these three patients, and in each case, the addition of autologous mononuclear cells at a 1:1 ratio abrogated the effect of HC on CFU-Eo. As studied in two of the three cases, IL-1 and IL-2 were able to prevent the effect of HC. Further studies showed no effect of HC when monocyte T cell-depleted marrow cells were used as the target population. These results suggest that CFU-Eo production in eosinophilic states is subject to modulation by HC and T lymphocytes. |
| Databáze: | OpenAIRE |
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