Paraneoplastic thrombocytosis-induced systemic thromboembolism in a cat

Autor: D D Sisson, Daniel F. Hogan, R S Dhaliwal, B E Kitchell
Rok vydání: 1999
Předmět:
Zdroj: Journal of the American Animal Hospital Association. 35:483-486
ISSN: 1547-3317
0587-2871
DOI: 10.5326/15473317-35-6-483
Popis: A six-year-old cat presented with clinical signs consistent with distal aortic thromboembolism while clinical signs of cardiovascular disease were absent. Diagnostics, including thoracic radiographs, electrocardiography, and echocardiography revealed no cardiovascular anomalies. Thoracic radiographs revealed multifocal pulmonary lesions consistent with neoplasia. Complete blood cell count demonstrated a marked thrombocytosis, leukopenia, and neutropenia. Histopathology of the pulmonary lesions confirmed multiple bronchoalveolar carcinomas. Myelodysplasia with megakaryocytic hyperplasia and ineffective myelopoiesis was noted on bone-marrow histopathology from multiple sites. The absence of other causes suggested a paraneoplastic thrombocytosis. The diagnosis of paraneoplastic thrombocytosis-induced thromboembolism was made due to the lack of underlying cardiac disease and the presence of a marked thrombocytosis. The presence of thrombocytosis and thromboembolism associated with neoplasia is discussed.
Databáze: OpenAIRE