Early-pregnancy maternal heart rate is related to gestational diabetes mellitus (GDM)
| Autor: | Jingbo Qiu, Wei Zhu, Xiaohua Wang, Chen Lei |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
medicine.medical_specialty endocrine system diseases Body Mass Index Heart Rate Pregnancy Risk Factors Diabetes mellitus Heart rate medicine Humans Family history Retrospective Studies medicine.diagnostic_test Obstetrics business.industry Parturition nutritional and metabolic diseases Obstetrics and Gynecology Infant medicine.disease Gestational diabetes Diabetes Gestational Blood pressure Reproductive Medicine Quartile Female Lipid profile business Body mass index |
| Zdroj: | European journal of obstetrics, gynecology, and reproductive biology. 268 |
| ISSN: | 1872-7654 |
| Popis: | Objective The study examined the association between resting heart rate (RHR) of early pregnancy and risk of gestational diabetes mellitus (GDM) in Chinese population. Methods As retrospective study, medical data of 15,092 pregnant women gave birth in 2019 was collected and analyzed. The pregnant women's age, educational level, pre-pregnancy body weight, height, parity, family history of diabetes, lipid profile, blood pressure and RHR were recorded during 11 ∼ 13+6 weeks. Multivariate logistic regression analysis was used to estimate the association between maternal characteristics and RHR and GDM. And we further evaluated the predictive roll of RHR in different sub-groups defined by their body mass index (BMI), age, fasting plasma glucose (FPG), total cholesterol and triglyceride. Results 2313 women (15.33%) were diagnosed as GDM according to 75 g OGTT. According to the quartile value of RHR, the subjects were divided into four groups. Risk of GDM increased significantly as RHR increased. In the fully adjusted model, ORs(95%CI) for the lowest vs highest quartiles of heart rate were 1(as reference), 1.14(0.97 ∼ 1.33), 1.25(1.05 ∼ 1.40), 1.41(1.21 ∼ 1.62), respectively. In the subgroup's analysis, we found the relationship between RHR and risk of GDM was evident in women with low and normal BMI; with normal fasting plasma; and normal serum lipid level. Conclusion The current study shows early-pregnancy maternal RHR is associated with potential risk of developing GDM. |
| Databáze: | OpenAIRE |
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