Probable Corticosteroid-Induced Reactivation of Latent Hepatitis B Virus Infection in an HIV-Positive Patient Involving Immune Escape
| Autor: | Alan Kay, Mary-Anne Trabaud, Christian Trepo, Nora Martel, Selma A. Gomes, Laurent Cotte, Fabien Zoulim |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Hepatitis B virus Genotype Anti-HIV Agents Mutation Missense HIV Infections medicine.disease_cause Epitope Virus Serology Epitopes Antigen Adrenal Cortex Hormones Antiretroviral Therapy Highly Active Administration Inhalation medicine Humans Immunology and Allergy Protease inhibitor (pharmacology) Hepatitis B Antibodies Immune Evasion Hepatitis B Surface Antigens biology virus diseases Middle Aged Hepatitis B Virology digestive system diseases Infectious Diseases Amino Acid Substitution Immunology biology.protein Virus Activation Antibody Immunosuppressive Agents |
| Zdroj: | The Journal of Infectious Diseases. 205:1757-1761 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jis268 |
| Popis: | We describe a patient infected with human immunodeficiency virus who possessed a serological profile suggesting a previous cleared acute hepatitis B virus (HBV) infection, including high levels of antibodies against HBV surface antigen (anti-HBs). Following the administration of inhaled glucocorticosteroids combined with protease inhibitor-based antiretroviral treatment, the patient developed an unexpected severe acute hepatitis despite persistence of anti-HBs. A genotype A2 strain emerged with 2 major mutations in the S gene, sK122R and sD144E. Molecular and biological analyses strongly suggested reactivation of a latent HBV infection. The importance and the molecular basis of these 2 epitopes in immune-escape mechanisms and host-virus interactions are discussed. |
| Databáze: | OpenAIRE |
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