Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms
| Autor: | Cody A. Boyle, Binqi Hu, Saobo Lei |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Phosphatidylinositol 4 5-Diphosphate Potassium Channels Cognitive Neuroscience Long-Term Potentiation Phospholipase C beta TRPV1 Action Potentials TRPV Cation Channels Hippocampus Oxytocin Membrane Potentials 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine medicine Animals Calcium Signaling Receptor Protein Kinase C 030304 developmental biology Neurons 0303 health sciences Chemistry Subiculum Long-term potentiation Depolarization Oxytocin receptor Rats nervous system Receptors Oxytocin Female Original Article Neuroscience hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery Signal Transduction medicine.drug |
| Zdroj: | Cereb Cortex |
| ISSN: | 1460-2199 1047-3211 |
| Popis: | Oxytocin (OXT) is a nonapeptide that serves as a neuromodulator in the brain and a hormone participating in parturition and lactation in the periphery. The subiculum is the major output region of the hippocampus and an integral component in the networks that process sensory and motor cues to form a cognitive map encoding spatial, contextual, and emotional information. Whilst the subiculum expresses the highest OXT-binding sites and is the first brain region to be activated by peripheral application of OXT, the precise actions of OXT in the subiculum have not been determined. Our results demonstrate that application of the selective OXT receptor (OXTR) agonist, [Thr4,Gly7]-oxytocin (TGOT), excited subicular neurons via activation of TRPV1 channels, and depression of K+ channels. The OXTR-mediated excitation of subicular neurons required the functions of phospholipase Cβ, protein kinase C, and degradation of phosphatidylinositol 4,5-bisphosphate (PIP2). OXTR-elicited excitation of subicular neurons enhanced long-term potentiation via activation of TRPV1 channels. Our results provide a cellular and molecular mechanism to explain the physiological functions of OXT in the brain. |
| Databáze: | OpenAIRE |
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