Effect of adjunctive sodium hyaluronate versus surfactant nasal irrigation on mucociliary clearance in allergic rhinitis: a single-blind, randomised, controlled study
| Autor: | Emre Mirici, Elif Dağlı, Emre Ocak, Aydın Acar, Deniz Kocaöz, Selcuk Mulazimoglu |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Adolescent Mucociliary clearance medicine.medical_treatment Sodium hyaluronate Severity of Illness Index Surface-Active Agents Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pulmonary surfactant medicine Humans Single-Blind Method In patient Prospective Studies Hyaluronic Acid 030223 otorhinolaryngology Prospective cohort study Aged business.industry General Medicine Middle Aged Combined Modality Therapy Rhinitis Allergic Nasal irrigation 030228 respiratory system Otorhinolaryngology chemistry Mucociliary Clearance Anesthesia Nasal Lavage Female Single blind business |
| Zdroj: | The Journal of Laryngology & Otology. 135:529-532 |
| ISSN: | 1748-5460 0022-2151 |
| Popis: | ObjectiveTo investigate the effects of nasal irrigation with sodium hyaluronate and surfactant solutions on mucociliary clearance time in patients with mild persistent allergic rhinitis.MethodsA total of 120 patients diagnosed with mild persistent allergic rhinitis were enrolled in this prospective study. The patients were allocated randomly to the surfactant, sodium hyaluronate or isotonic saline (as a control) nasal irrigation group. The mucociliary clearance times and improvements in mucociliary clearance times were compared.ResultsImprovements in mean mucociliary clearance time were significantly greater in the surfactant and sodium hyaluronate groups than in the control group (p < 0.01). The mean post-treatment mucociliary clearance time of the surfactant group was significantly lower than that of the control (p < 0.001) and sodium hyaluronate groups (p = 0.03).ConclusionSurfactant and sodium hyaluronate nasal irrigation solutions may both be used as adjunctive treatments for allergic rhinitis. Surfactant nasal irrigation resulted in better mucociliary clearance times. |
| Databáze: | OpenAIRE |
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