Central pipecolic acid increases food intake under ad libitum feeding conditions in the neonatal chick
| Autor: | Tetsuya Tachibana, Tomo Takagi, Shouzou Tomonaga, Takashi Bungo, Mitsuhiro Furuse, D. Michael Denbow, Ei Suke Saito, Shin Saito |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Lysine Endogeny Biology GABA Antagonists Eating chemistry.chemical_compound Organophosphorus Compounds Internal medicine medicine Animals Picrotoxin Neurotransmitter Receptor Injections Intraventricular Pipecolic acid General Neuroscience Stereoisomerism Metabolic intermediate Receptors GABA-A Receptor antagonist Endocrinology Animals Newborn Receptors GABA-B chemistry Pipecolic Acids Chickens |
| Zdroj: | Neuroscience Letters. 347:93-96 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/s0304-3940(03)00701-8 |
| Popis: | It has been demonstrated that l -pipecolic acid (L-PA) is a major metabolic intermediate of l -lysine in the mammalian and chicken brain. A previous study showed that intracerebroventricular (i.c.v.) injection of L-PA suppressed feeding in neonatal chicks, and the actions were associated with γ-aminobutyric acid (GABA)-B receptor activation. It has been reported that endogenous L-PA in the brain fluctuated under different feeding conditions. In the present study, we investigated the effect of i.c.v. injection of L-PA on food intake in the neonatal chick under ad libitum feeding conditions. The food intake was increased by 0.5 or 1.0 mg L-PA under ad libitum feeding conditions contrary to previous studies using fasted birds. A hyperphagic effect of L-PA (0.5 mg) was attenuated by both GABA-A receptor antagonist (picrotoxin, 0.5 μg) and GABA-B receptor antagonist (CGP54626, 21.0 ng). These results indicate that a hyperphagic effect of L-PA is mediated by both GABA-A and GABA-B receptors and L-PA differentially affects food intake under different feeding conditions in the neonatal chick. |
| Databáze: | OpenAIRE |
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