A pilot, double-blind, placebo-controlled trial of pregabalin (Lyrica) in the treatment of essential tremor
| Autor: | Theresa A. Zesiewicz, Kelly L. Sullivan, Maria Carmen Wilson, Jason L. Salemi, Robert A. Hauser, Shaila Siraj, Christopher L. Ward |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Time Factors Essential Tremor Pregabalin Placebo-controlled study Pilot Projects Placebo law.invention Double-Blind Method Randomized controlled trial law medicine Humans gamma-Aminobutyric Acid Essential tremor business.industry Middle Aged medicine.disease Action tremor Clinical trial Neurology Tolerability Anesthesia Anticonvulsants Female Neurology (clinical) business medicine.drug |
| Zdroj: | Movement Disorders. 22:1660-1663 |
| ISSN: | 1531-8257 0885-3185 |
| Popis: | We performed a pilot, double-blind, placebo-controlled, randomized trial to evaluate the efficacy and tolerability of pregabalin (PGB, Lyrica), an antiepileptic agent, in treating essential tremor (ET). Twenty two patients with ET were randomly assigned to receive PGB or placebo. PGB was initiated at 50 mg/day and was escalated by 75 mg/day every 4 days to a maximum dose of 600 mg/day. Patients were evaluated by accelerometry and the Fahn-Tolosa-Marin (FTM) rating scale. There was a significant reduction in tremor amplitude in the PGB group compared with the placebo group, as measured by accelerometry, at a mean dose of 286.76+/-100.05 mg/day. Action tremor limb scores on the FTM also improved in the PGB group compared with the placebo group (P-value for multilevel modeling=0.04). PGB was fairly well tolerated, with about one-third of patients dropping out of the study because of adverse events. PGB provided significant improvements in accelerometry and in action tremor limb scores on the FTM. However, larger studies are needed to further evaluate the potential effect of PGB on ET. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text