Avian oncogenesis induced by lymphoproliferative disease virus: a neglected or emerging retroviral pathogen?
| Autor: | Anne Lichtenwalner, M. Kevin Keel, Edward C. Holmes, Trista I. Welsh, Jamie E. Philips, Jesse Thomas, Aly M. Fadly, Nicole M. Nemeth, James M. Crum, Andrew N. Cartoceti, Andrew B. Allison, Guillermo Zavala, Brandon A. Munk, Justin C. Brown |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Turkeys
Tumor Virus Infections Lineage (genetic) Old World Evolution Carcinogenesis Order Galliformes Molecular Sequence Data Lymphoproliferative disease virus (LPDV) Alpharetrovirus Communicable Diseases Medical and Health Sciences Communicable Diseases Emerging Virus Article Evolution Molecular Avian tumor viruses Retrovirus Virology Genetics 2.1 Biological and endogenous factors Animals Aetiology Oncogenesis Phylogeny Poultry Diseases Cancer Emerging biology Agricultural and Veterinary Sciences Outbreak Molecular Neglected Diseases Provirus Biological Sciences biology.organism_classification Lymphoproliferative disease virus United States 3. Good health Infectious Diseases Exogenous retrovirus Infection Retroviridae Infections |
| Popis: | Lymphoproliferative disease virus (LPDV) is an exogenous oncogenic retrovirus that induces lymphoid tumors in some galliform species of birds. Historically, outbreaks of LPDV have been reported from Europe and Israel. Although the virus has previously never been detected in North America, herein we describe the widespread distribution, genetic diversity, pathogenesis, and evolution of LPDV in the United States. Characterization of the provirus genome of the index LPDV case from North America demonstrated an 88% nucleotide identity to the Israeli prototype strain. Although phylogenetic analysis indicated that the majority of viruses fell into a single North American lineage, a small subset of viruses from South Carolina were most closely related to the Israeli prototype. These results suggest that LPDV was transferred between continents to initiate outbreaks of disease. However, the direction (New World to Old World or vice versa), mechanism, and time frame of the transcontinental spread currently remain unknown. |
| Databáze: | OpenAIRE |
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