Successful integration of HIV pre-exposure prophylaxis into a community-based HIV prevention program for female sex workers in Kolkata, India
| Autor: | Bharat B Rewari, Marissa Becker, Raman R. Gangakhedkar, Soma Roy, Protim Ray, Abhijit Kadam, Smarajit Jana, Stephen Moses |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Anti-HIV Agents Human immunodeficiency virus (HIV) India HIV Infections Context (language use) Dermatology 030312 virology medicine.disease_cause Emtricitabine Medication Adherence 03 medical and health sciences Pre-exposure prophylaxis 0302 clinical medicine Community support Original Research Articles medicine Humans Pharmacology (medical) 030212 general & internal medicine female sex workers Community based 0303 health sciences Sex Workers business.industry Public Health Environmental and Occupational Health virus diseases HIV Female sex Retention rate Infectious Diseases Family medicine Female business medicine.drug |
| Zdroj: | International Journal of STD & AIDS |
| ISSN: | 1758-1052 0956-4624 |
| DOI: | 10.1177/0956462420983992 |
| Popis: | We assessed the impact of pre-exposure prophylaxis (PrEP) in the context of a community-based HIV program among female sex workers (FSWs) in Kolkata, India. This was an open-label, uncontrolled demonstration trial. HIV seronegative FSWs over 18 years were eligible. Participants were administered daily tenofovir/emtricitabine (TDF-FTC) with follow-up visits at months 1, 3, 6, 9, 12, and 15. Drug adherence was monitored by self-report, and a random subset of participants underwent plasma TDF testing. 843 women were screened and 678 enrolled and started on PrEP. Seventy-nine women (11%) did not complete all scheduled visits: four women died of reasons unrelated to PrEP and 75 withdrew, for a 15-month retention rate of 89%. Self-reported daily adherence was over 70%. Among those tested for TDF, the percentage of women whose level reached ≥40 ng/mL was 65% by their final visit. There were no HIV seroconversions, and no evidence of significant changes in sexual behavior. This study demonstrated the feasibility and effectiveness of PrEP for FSWs in Kolkata, with very high levels of adherence to PrEP and no HIV seroconversions. The integration of PrEP into an existing community-based HIV prevention program ensured community support and facilitated adherence. |
| Databáze: | OpenAIRE |
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