Contrast-enhanced ultrasound for imaging vasa vasorum: comparison with histopathology in a swine model of atherosclerosis
| Autor: | Juan F. Granada, Chris G. Krueger, Blai Coll, Steven B. Feinstein, Daniel Staub, Jess D. Reed, Greg L. Kaluza, William Zang, Arend F.L. Schinkel, Cindy Owens, Anne L. Hall, Folkert J. ten Cate, Armando Tellez |
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| Přispěvatelé: | Cardiology |
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Pathology Time Factors Arteriosclerosis Swine Contrast Media Femoral artery medicine.disease_cause Hyperlipoproteinemia Type II medicine.artery medicine Animals Radiology Nuclear Medicine and imaging Radionuclide Imaging Ultrasonography business.industry Vasa Vasorum Ultrasound General Medicine medicine.disease Vulnerable plaque Disease Models Animal medicine.anatomical_structure Atheroma Intima-media thickness Vasa vasorum cardiovascular system Disease Progression Histopathology Tunica Intima Tunica Media Cardiology and Cardiovascular Medicine business Contrast-enhanced ultrasound |
| Zdroj: | European Journal of Echocardiography, 11(8), 659-664. Oxford University Press Scopus-Elsevier |
| ISSN: | 1532-2114 1525-2167 |
| DOI: | 10.1093/ejechocard/jeq048 |
| Popis: | Aim To evaluate the agreement between contrast-enhanced ultrasound imaging and histopathology in an animal model of atherosclerosis. Methods and results Atherosclerosis was studied in both femoral arteries of four Rapacz familial hypercholesterolaemia (RFH) swine. Contrast-enhanced ultrasound imaging of the eight femoral arteries was performed at baseline and at 5, 12, 26, and 43 weeks follow-up after percutaneous transluminal stimulation of atherosclerosis to assess the progression of intima-media thickness (IMT) and the density and extent of the vasa vasorum network. Contrast-enhanced ultrasound imaging allowed an early detection of atherosclerosis and showed a significant gradual progression of atherosclerosis over time. IMT increased from 0.22 ± 0.05 mm at baseline to 0.45 ± 0.06 mm ( P < 0.001) at follow-up. The density of the vasa vasorum network increased during follow-up and was significantly higher in advanced than in early atherosclerosis. The findings with contrast-enhanced ultrasound were confirmed by histopathological specimens of the arterial wall. Conclusion Contrast-enhanced ultrasound is effective for in vivo detection of vasa vasorum in atherosclerotic plaques in the RFH swine model. After stimulation of atherosclerosis, contrast-enhanced ultrasound demonstrated a significantly increased IMT and significantly increased density of the vasa vasorum network in the developing atherosclerotic plaque, which was validated by histology. |
| Databáze: | OpenAIRE |
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