Periodontal regeneration by leukocyte and platelet-rich fibrin with autogenous bone graft versus enamel matrix derivative with autogenous bone graft in the treatment of periodontal intrabony defects: A randomized non-inferiority trial
| Autor: | Marta Giraudi, Marcella Di Tullio, Giulia Paolantonio, Beatrice Femminella, Filippo Graziani, Andrea Pilloni, Luigi Romano, Lorenzo Secondi, Michele Paolantonio, Paolo De Ninis |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Bone Regeneration medicine.medical_treatment Radiography Alveolar Bone Loss Dentistry wound healing Fibrin 03 medical and health sciences 0302 clinical medicine Dental Enamel Proteins Platelet-Rich Fibrin Enamel matrix derivative grafts Periodontal Attachment Loss medicine Leukocytes Humans Regeneration Clinical significance Gingival Recession Gingival recession Reduction (orthopedic surgery) clinical trials biology business.industry 030206 dentistry Platelet-rich fibrin 030104 developmental biology Treatment Outcome biology.protein Guided Tissue Regeneration Periodontal Periodontics medicine.symptom business Wound healing dental enamel proteins platelet-rich fibrin regeneration |
| Zdroj: | Journal of periodontologyREFERENCES. 91(12) |
| ISSN: | 1943-3670 |
| Popis: | Background Aim of the present study was to ascertain if a combination of leukocyte and platelet-rich fibrin (L-PRF) + autogenous bone graft (ABG) may be a clinically "non-inferior" treatment modality as compared with the association of enamel matrix derivative (EMD) with ABG in the management of intrabony defects (IBDs). Methods A total of forty-four patients, exhibiting at least one unfavorable intraosseous defect, were treated by L-PRF associated with ABG (22 patients; test group) or EMD+ABG (control group) in each defect. At baseline and 12 months, a complete clinical and radiographic examination was done. Pre- and post-therapy clinical (probing pocket depth [PPD], clinical attachment level [CAL], gingival recession [GR]) and radiographic (defect Bone level [(DBL)] parameters for the different treatments were compared. To guarantee the test treatment's efficacy 1mm was chosen as non-inferiority margin; for clinical relevance, a second non-inferiority margin = 0.5 mm was set. Results Clinical and radiographic parameters significantly improved 12 months after surgery in both test and control sites, without inter-groups differences for each measurement. The control group - test group differences for the parameters CAL gain -0.248 mm (-0.618 to 0.122), PPD Reduction -0.397 mm (-0.810 to 0.015), GR Change 0.059 mm (-0.300 to 0.418), DBL Gain -0.250 mm (-0.746 to 0.246) were all within the non-inferiority margin of 0.5 mm. Conclusion Our results suggest that the L-PRF+ABG combined treatment of non-contained IBDs produces non-inferior results in terms of CAL gain, PPD reduction, GR increase and DBL gain in comparison with the EMD+ABG combination. |
| Databáze: | OpenAIRE |
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