Dopamine as an anorectic neuromodulator in the cockroachRhyparobia maderae
| Autor: | Brooke H. Van Kummer, Jaclyn M. Allen, Randy W. Cohen |
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| Rok vydání: | 2011 |
| Předmět: |
Agonist
Spiperone medicine.medical_specialty Tetrahydronaphthalenes Chlorpromazine Physiology medicine.drug_class Dopamine Cockroaches Aquatic Science Eating chemistry.chemical_compound biology.animal Internal medicine medicine Animals Neurotransmitter Nymph Molecular Biology Ecology Evolution Behavior and Systematics Neurotransmitter Agents Cockroach biology Antagonist Endocrinology chemistry Insect Science Dopamine Agonists Anorectic Dopamine Antagonists Animal Science and Zoology medicine.drug |
| Zdroj: | Journal of Experimental Biology. 214:3843-3849 |
| ISSN: | 1477-9145 0022-0949 |
| Popis: | SUMMARYInsects, including cockroaches, self-select a balanced diet when faced with different nutrient choices. For self-selection to be carried out effectively, insects possess neuroregulatory systems to control their food intake. In the present study, we examined the role of the neurotransmitter dopamine (DA) in the feeding regulation of the Madeira cockroach (Rhyparobia maderae). When R. maderae nymphs were injected with 20 μl of 100 mmol l–1 DA, they showed an 83.3% reduction in sucrose intake and a 78.9% reduction in total intake compared with saline-injected controls. The DA agonist, 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (6,7-ADTN) (100 mmol l–1 in 1 μl), caused a significant reduction in sucrose feeding, reducing feeding by 47.3% compared with saline-injected controls. Protein feeding was also significantly reduced by 6,7-ADTN to 62%. Rhyparobia maderae nymphs injected with the DA antagonist chlorpromazine (100 mmol l–1 in 1 μl) did not differ significantly from control nymphs in their feeding behavior. Interestingly, R. maderae nymphs injected with 2 μl or 5 μl chlorpromazine (100 mmol l–1) showed significantly increased mortality rates of 47.5% or 66.7%, respectively. The DA antagonist, spiperone (100 mmol l–1 in 1 μl), caused a significant feeding response, showing an increase in feeding in both sucrose (310.6%) and total intake (236.3%). Casein feeding in R. maderae nymphs was also elevated (70.8%) but this was not statistically significant. The experiments with DA, the DA agonist 6,7-ADTN and the DA antagonist spiperone strongly suggest that the neurotransmitter DA is involved in regulating feeding in the cockroach R. maderae. |
| Databáze: | OpenAIRE |
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