Clinical characteristics and outcome of hospitalized elderly patients with COVID- 19 after vaccine failure

Autor:	M. Díaz-Menéndez, F. de la Calle-Prieto, R. Montejano, M. Arsuaga, M. Jiménez-González, V. Pérez-Blanco, C. Marcelo, J Vásquez-Manau, F. Lázaro, J.R. Arribas
Rok vydání:	2021
Předmět:	Aged 80 and over Male COVID-19 Vaccines General Veterinary General Immunology and Microbiology SARS-CoV-2 Public Health Environmental and Occupational Health COVID-19 Comorbidity Hospitalization Infectious Diseases Molecular Medicine Humans Female Aged
Zdroj:	Vaccine. 40(32)
ISSN:	1873-2518
Popis:	We described clinical characteristics and outcome of 160 patients over 65 years (01 September to 31 August 2021) who had a first positive SARS-CoV-2 PCR- test more than 14 days after full vaccination and were hospitalized with COVID-19. Median age of included patients was 84 years, 61.2% were over 80 years; 50.6% were male and most (82.5%) has at least one comorbidity. Up to 84% received specific treatment against COVID-19, including 76.9% low-flow oxygen therapy. We found that overall mortality was 25.6% and 30.6% in those older than 80 years. A higher mortality was significantly associated with older age and treatment with tocilizumab. Our data showed that although COVID-19 vaccines continue protecting elderly patients against hospitalization and death and might improve the prognosis after hospitalization in patients with breakthrough infections, mortality in this population -especially in those older than 80 years- remains very high.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb72696ef35c024c257f1e7983f2f8f2 https://pubmed.ncbi.nlm.nih.gov/35701328 Zobrazit plný text záznamu Full Text from ScienceDirect