Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America

Autor: Lolke van der Veen, Luísa Pereira, Paul Verdu, Florence Migot-Nabias, Etienne Patin, Hélène Quach, Lluis Quintana-Murci, Luis B. Barreiro, Achille Massougbodji, Marie Lopez, Cesar Fortes-Lima, Gil Bellis, Christine Harmant, Carlos Bustamante, George H. Perry, Rebecca Grollemund, Jean-Marie Hombert, Evelyne Heyer, Joana B. Pereira, Guillaume Laval, Patrick Mouguiama-Daouda, Alain Froment, Verónica Fernandes, Jean-Michel Dugoujon
Přispěvatelé: Génétique Evolutive Humaine - Human Evolutionary Genetics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Eco-Anthropologie et Ethnobiologie (EAE), Muséum national d'Histoire naturelle (MNHN)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Éco-Anthropologie (EA), parasitology and mycology education, Science and health faculty, Mère et enfant face aux infections tropicales (MERIT - UMR_D 216), Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5), Institut national d'études démographiques (INED), Anthropologie Moléculaire et Imagerie de Synthèse (AMIS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Instituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto [Porto], Dynamique Du Langage (DDL), Université Lumière - Lyon 2 (UL2)-Centre National de la Recherche Scientifique (CNRS), Affymetrix, This work was funded by the Institut Pasteur, the Centre National de la Recherche Scientifique (CNRS), Agence Nationale de la Recherche (ANR) grant AGRHUM (ANR-14-CE02-0003-01), and the 'Histoire du Génome des Populations Humaines Gabonaises' project (Institut Pasteur/Republic of Gabon). The newly generated SNP genotype data have been deposited in the European Genome-Phenome Archive under accession code EGAS00001002078., ANR-14-CE02-0003,AGRHUM,Etude de l'adaptation génétique aux changements environnementaux rapides : l’agriculture et le modèle humain(2014), Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 216), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Universidade do Porto, ANR-14-CE02-0003,AGRHUM,Etude de l'adaptation génétique aux changements environnementaux rapides : l'agriculture et le modèle humain(2014), Instituto de Investigação e Inovação em Saúde, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Universidade do Porto = University of Porto
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Expansion
History
[SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology
Bantu languages
MESH: HLA Antigens/genetics
MESH: African Americans/genetics
HLA Antigens
Lactase
Language
Multidisciplinary
Natural selection
Genome
MESH: Rainforest
Human migration
MESH: Polymorphism
Single Nucleotide
MESH: Speech
Adaptation
Physiological
Geography
MESH: Human Migration
MESH: Language
Ethnology
Rainforest
Human Migration
Genomic data
Admixture
Polymorphism
Single Nucleotide
MESH: Genetic Loci
03 medical and health sciences
Humans
Speech
Africa
Central
Selection
Ancestry
[SDV.GEN]Life Sciences [q-bio]/Genetics
MESH: Humans
business.industry
Central africa
MESH: Adaptation
Physiological/genetics
MESH: North America
Black or African American
MESH: Africa
Central
030104 developmental biology
MESH: Lactase/genetics
Genetic Loci
North America
Adaptation
business
Genetic adaptation
Zdroj: Science
Science, American Association for the Advancement of Science, 2017, 356 (6337), pp.543-546. ⟨10.1126/science.aal1988⟩
Science (New York, N.Y.)
Science, 2017, 356 (6337), pp.543-546. ⟨10.1126/science.aal1988⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ISSN: 0036-8075
1095-9203
Popis: Bantu languages are spoken by about 310 million Africans, yet the genetic history of Bantu-speaking populations remains largely unexplored. We generated genomic data for 1318 individuals from 35 populations in western central Africa, where Bantu languages originated. We found that early Bantu speakers first moved southward, through the equatorial rainforest, before spreading toward eastern and southern Africa. We also found that genetic adaptation of Bantu speakers was facilitated by admixture with local populations, particularly for the HLA and LCT loci. Finally, we identified a major contribution of western central African Bantu speakers to the ancestry of African Americans, whose genomes present no strong signals of natural selection. Together, these results highlight the contribution of Bantu-speaking peoples to the complex genetic history of Africans and African Americans. This work was funded by the Institut Pasteur, the Centre National de la Recherche Scientifique (CNRS), Agence Nationale de la Recherche (ANR) grant AGRHUM (ANR-14-CE02-0003-01), and the “Histoire du Génome des Populations Humaines Gabonaises” project (Institut Pasteur/Republic of Gabon).
Databáze: OpenAIRE
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