Viral hepatitis and pregnancy
| Autor: | Miriam T. Levy, Norah A. Terrault, Ka Wang Cheung, Gonzague Jourdain |
|---|---|
| Přispěvatelé: | Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]) |
| Rok vydání: | 2020 |
| Předmět: |
MESH: Antiviral Agents
0301 basic medicine MESH: Premature Birth MESH: Hepatitis Chronic viruses Hepatitis C virus medicine.disease_cause 03 medical and health sciences Liver disease MESH: Perinatal Mortality MESH: Pregnancy 0302 clinical medicine medicine MESH: Infant Mortality MESH: Pregnancy Complications Infectious MESH: Hepatitis Viral Human MESH: Diabetes Gestational MESH: Hepatitis C Hepatitis Hepatitis B virus MESH: Hepatitis D MESH: Humans MESH: Hepatitis A MESH: Hepatitis B Hepatology MESH: Viral Hepatitis Vaccines business.industry MESH: Infant Newborn MESH: Hepatitis E Gastroenterology Hepatitis A MESH: Pregnancy Outcome medicine.disease MESH: Infant 3. Good health MESH: Infectious Disease Transmission Vertical 030104 developmental biology Immunology MESH: Acute Disease 030211 gastroenterology & hepatology MESH: Maternal Mortality Hepatitis D virus MESH: Liver Cirrhosis MESH: Viral Load Viral hepatitis business MESH: Female Viral load [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Nature reviews. Gastroenterology & hepatology Nature reviews. Gastroenterology & hepatology, Nature Publishing Group, 2009-, 2021, 18 (2), pp.117-130. ⟨10.1038/s41575-020-00361-w⟩ |
| ISSN: | 1759-5053 1759-5045 |
| DOI: | 10.1038/s41575-020-00361-w |
| Popis: | The management of viral hepatitis in the setting of pregnancy requires special consideration. There are five liver-specific viruses (hepatitis A, B, C, D, E), each with unique epidemiology, tendency to chronicity, risk of liver complications and response to antiviral therapies. In the setting of pregnancy, the liver health of the mother, the influence of pregnancy on the clinical course of the viral infection and the effect of the virus or liver disease on the developing infant must be considered. Although all hepatitis viruses can harm the mother and the child, the greatest risk to maternal health and subsequently the fetus is seen with acute hepatitis A virus or hepatitis E virus infection during pregnancy. By contrast, the primary risks for hepatitis B virus (HBV), hepatitis C virus (HCV) and hepatitis D virus are related to the severity of the underlying liver disease in the mother and the risk of mother-to-child transmission (MTCT) for HBV and HCV. The prevention of MTCT is key to reducing the global burden of chronic viral hepatitis, and prevention strategies must take into consideration local health-care and socioeconomic challenges. This Review presents the epidemiology of acute and chronic viral hepatitis infection in pregnancy, the effect of pregnancy on the course of viral infection and, conversely, the influence of the viral infection on maternal and infant outcomes, including MTCT. The management of viral hepatitis in the setting of pregnancy requires special consideration. This Review examines each hepatitis virus individually to address the effect of pregnancy on the natural history of infection and how the viral infections influence maternal and infant outcomes, including mother-to-child transmission. |
| Databáze: | OpenAIRE |
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