Extent of Resection and Long-Term Survival of Pineal Region Tumors in Helsinki Neurosurgery
| Autor: | Julio C. Resendiz-Nieves, Olli Tynninen, Juha Hernesniemi, Juho Vehviläinen, Mika Niemelä, Behnam Rezai Jahromi, Joham Choque-Velasquez, Rahul Raj, Roberto Colasanti, Juhani Collan |
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| Přispěvatelé: | Clinicum, HUS Neurocenter, Neurokirurgian yksikkö, University of Helsinki, Staff Services, Helsinki University Hospital Area, Medicum, HUSLAB, Department of Pathology, Department of Oncology, HUS Comprehensive Cancer Center, Department of Neurosciences |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Microsurgery Survival Pineal Gland Neurosurgical Procedures 3124 Neurology and psychiatry 0302 clinical medicine Pineal tumors Meningeal Neoplasms Child Finland Aged 80 and over Brain Neoplasms Glioma Sitting position Middle Aged Neoplasms Germ Cell and Embryonal 3. Good health Tumor Burden Chemotherapy Adjuvant 030220 oncology & carcinogenesis Child Preschool Female Radiology Neurosurgery Microneurosurgery Meningioma Pinealoma Adult medicine.medical_specialty Adolescent PRESERVING NORMAL ANATOMY Supracerebellar infratentorial approach Astrocytoma Extent of resection 03 medical and health sciences Intermediate differentiation Young Adult Long term survival Multidisciplinary management medicine Humans Radiochemotherapy Aged Retrospective Studies business.industry 3112 Neurosciences Infant Retrospective cohort study medicine.disease 3126 Surgery anesthesiology intensive care radiology PRINCIPLES Pineal region lesions EXPERIENCE Surgery Radiotherapy Adjuvant Neurology (clinical) Germ cell tumors business 030217 neurology & neurosurgery Pineal region tumors |
| Popis: | BACKGROUND: Pineal region tumors represent challenging surgical lesions with wide ranges of survival reported in different surgical series. In this article, we emphasize the role of complete microsurgical resection (CMR) to obtain a favorable long-term outcome of pineal region tumors. METHODS: We report a retrospective study of pineal region tumors operated on in Helsinki Neurosurgery between 1997 and 2015. Information was obtained from the hospital records, and an evaluation of the Finnish population register was conducted in July 2018 to determine the current status of the patients. RESULTS: A total of 76 pineal region tumors were operated on. The survival was 62% at a mean follow-up of 125 +/- 105 months (range, 0-588 months), and the disease-related mortality was limited to 14 patients (18.4%). Up to July 2018, 29 patients had died. Two patients died 1 and 3 months after surgery of delayed thalamic infarctions, 12 patients of disease progression, and 15 had non-disease-related deaths. Only 1 patient was lost in the long-term follow-up. Ten of 14 disease-related deaths occurred during the first 5 years of follow-up: 5 diffuse gliomas, 3 germ cell tumors, 1 grade II-III pineal parenchymal tumor of intermediate differentiation, and 1 meningioma. CMR was linked to better tumor-free survival and long-term survival, with the exception of diffuse gliomas. CONCLUSIONS: CMR, in the setting of a multidisciplinary management of pineal region tumors, correlates with favorable survival and with minimal mortality. Surgically treated grade II-IV gliomas constitute a particular group with high mortality within the first 5 years independently of the microsurgical resection. |
| Databáze: | OpenAIRE |
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