Initial success from a public health approach to hepatitis C testing, treatment and cure in seven countries: the road to elimination
Autor: | Grace Singh, Sabin Nsanzimana, Nguyen Van Kinh, Alida Ngwije, Wiendra Waworuntu, Emi Okamoto, Chukwuemeka Agwuocha, Ly Penh Sun, Siddharth Sindhwani, Hlaing Thazin Aung, Khin Sanda Aung, Gagandeep Singh Grover, Caroline E. Boeke, Atiek Anartati, Craig McClure, Clement Adesigbin, Dang Ngo |
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Rok vydání: | 2020 |
Předmět: |
Economic growth
medicine.medical_specialty Service delivery framework Commodity India Nigeria viral hepatitis Myanmar diagnostics and tools Antiviral Agents lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine Chai Health care medicine Humans lcsh:RC109-216 030212 general & internal medicine health care economics and organizations lcsh:R5-920 Practice treatment business.industry Health Policy Public health Public sector public health Public Health Environmental and Occupational Health Hepatitis C Chronic Investment (macroeconomics) Hepatitis C Vietnam Expanded access 030211 gastroenterology & hepatology Business lcsh:Medicine (General) |
Zdroj: | BMJ Global Health BMJ Global Health, Vol 5, Iss 12 (2020) |
ISSN: | 2059-7908 |
Popis: | With political will, modest financial investment and effective technical assistance, public sector hepatitis C virus (HCV) programmes can be established in low- and middle-income countries as a first step towards elimination. Seven countries, with support from the Clinton Health Access Initiative (CHAI) and partners, have expanded access to HCV treatment by combining programme simplification with market shaping to reduce commodity prices. CHAI has supported a multipronged approach to HCV programme launch in Cambodia, India, Indonesia, Myanmar, Nigeria, Rwanda and Vietnam including pricing negotiations with suppliers, policy development, fast-track registrations of quality-assured generics, financing advocacy and strengthened service delivery. Governments are leading programme implementation, leveraging HIV programme infrastructure/financing and focusing on higher-HCV prevalence populations like people living with HIV, people who inject drugs and prisoners. This manuscript aims to describe programme structure and strategies, highlight current commodity costs and outline testing and treatment volumes across these countries. Across countries, commodity costs have fallen from >US$100 per diagnostic test and US$750–US$900 per 12-week pan-genotypic direct-acting antiviral regimen to as low as US$80 per-cure commodity package, including WHO-prequalified generic drugs (sofosbuvir + daclatasvir). As of December 2019, 5900+ healthcare workers were trained, 2 209 209 patients were screened, and 120 522 patients initiated treatment. The cure (SVR12) rate was >90%, including at lower-tier facilities. Programmes are successfully implementing simplified, decentralised public health approaches. Combined with political will and affordable pricing, these efforts can translate into commitments to achieve global targets. However, to achieve elimination, additional investment in scale-up is required. |
Databáze: | OpenAIRE |
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