Novel insights into the athlete’s heart: is myocardial work the new champion of systolic function?
| Autor: | Bálint András Barta, Béla Merkely, Alexandra Fábián, Bálint Károly Lakatos, Tamás Radovits, Nóra Sydó, Attila Oláh, Alex Ali Sayour, Orsolya Kiss, Mihály Ruppert, Istvan Hizoh, Márton Tokodi, Zsuzsanna Ladányi, Attila Kovács, Emese Csulak |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Systole Heart Ventricles Athlete's heart Rat model Speckle tracking echocardiography Systolic function Positive correlation contractility Ventricular Function Left Contractility Internal medicine Cardiopulmonary exercise test medicine Animals Humans Radiology Nuclear Medicine and imaging AcademicSubjects/MED00200 Cardiomegaly Exercise-Induced Original Paper business.industry Myocardium VO2 max General Medicine Myocardial Contraction Rats myocardial work Editor's Choice Editorial Cardiology Hypertrophy Left Ventricular Cardiology and Cardiovascular Medicine business athlete’s heart speckle-tracking echocardiography |
| Zdroj: | European Heart Journal Cardiovascular Imaging |
| ISSN: | 2047-2412 2047-2404 |
| Popis: | Aims We sought to investigate the correlation between speckle-tracking echocardiography (STE)-derived myocardial work (MW) and invasively measured contractility in a rat model of athlete's heart. We also assessed MW in elite athletes and explored its association with cardiopulmonary exercise test (CPET)-derived aerobic capacity. Methods and results Sixteen rats underwent a 12-week swim training program and were compared to controls (n = 16). STE was performed to assess global longitudinal strain (GLS), which was followed by invasive pressure-volume analysis to measure contractility [slope of end-systolic pressure–volume relationship (ESPVR)]. Global MW index (GMWI) was calculated from GLS curves and left ventricular (LV) pressure recordings. In the human investigations, 20 elite swimmers and 20 healthy sedentary controls were enrolled. GMWI was calculated through the simultaneous evaluation of GLS and non-invasively approximated LV pressure curves at rest. All subjects underwent CPET to determine peak oxygen uptake (VO2/kg). Exercised rats exhibited higher values of GLS, GMWI, and ESPVR than controls (−20.9 ± 1.7 vs. −17.6 ± 1.9%, 2745 ± 280 vs. 2119 ± 272 mmHg·%, 3.72 ± 0.72 vs. 2.61 ± 0.40 mmHg/μL, all PExercise < 0.001). GMWI correlated robustly with ESPVR (r = 0.764, P Graphical Abstract ESPVR, slope of end-systolic pressure–volume relationship (i.e. the slope of the curve connecting the end-systolic points of the pressure–volume loops recorded during the transient occlusion of inferior vena cava); GLS, global longitudinal strain; GMWI, global myocardial work index; LV, left ventricular; VO2/kg, peak oxygen uptake. |
| Databáze: | OpenAIRE |
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