Antiproliferative and cytotoxic secondary metabolites from fruits of Leplaea mayombensis
| Autor: | Soh Desire, Sidjui Sidjui Lazare, Shaiq Ali Muhammad, Wembe Ngouonpe Alain, Folefoc Ngosong Gabriel, Happi Tchakounté Brice, Toghueo Kouipou Rufin Marie, Dameue Tegang Joel Ebenezer |
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| Rok vydání: | 2017 |
| Předmět: |
Phytochemicals
Secondary Metabolism Plant Science 01 natural sciences Biochemistry Analytical Chemistry Terpene Mice Cell Line Tumor Animals Humans Cytotoxic T cell Cameroon Meliaceae Cytotoxicity Molecular Structure 010405 organic chemistry Chemistry Organic Chemistry 3T3 Cells Leplaea mayombensis Antineoplastic Agents Phytogenic Triterpenes 0104 chemical sciences 010404 medicinal & biomolecular chemistry Fruit Steroids HeLa Cells |
| Zdroj: | Natural Product Research. 33:635-641 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2017.1402321 |
| Popis: | Two new seco-lanostane-type triterpenes, named mayomlactones A (1) and B (2) were isolated from the fruits of Leplaea mayombensis together with 10 known compounds (3–12). Structures of the new compounds were elucidated by extensive spectroscopic studies. Except compounds 11 and 12, all the other chemical compounds are newly reported from Leplaea genus. From the results of this investigation, compounds 1–10 were examined for antiproliferative activity against HeLa cells as well as cytotoxicity against 3T3 cell line. Compounds 3 and 4 showed moderate antiproliferative activity with IC50 values of 10.4 ± 0.1 and 18.6 ± 0.2 μM, respectively. On the other hand, compounds 1, 4 and 9 showed weak cytotoxicity with IC50 values 44.1 ± 0.5, 55.8 ± 0.7 and 55.1 ± 0.5 μM. Overall, none of the tested compounds showed good selectivity (SI ranging from 0.51 to 3.06) but high toxicity against the 3T3 cell line. |
| Databáze: | OpenAIRE |
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