Care management of spasticity with botulinum toxin-A in patients with severe acquired brain injury: A 1-year follow-up prospective study
| Autor: | Rita Formisano, Giulio Cochi, Paola Cicinelli, Alessandro Clemenzi, Maria Matteis, Paola Savina, Luciano Gallinacci |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Neuroscience (miscellaneous) Botulinum toxin a Young Adult Developmental and Educational Psychology medicine Humans In patient Prospective Studies Spasticity Botulinum Toxins Type A Young adult Adverse effect Prospective cohort study Acquired brain injury Aged Rehabilitation business.industry Middle Aged medicine.disease body regions Treatment Outcome Neuromuscular Agents Muscle Spasticity Brain Injuries Physical therapy Female Neurology (clinical) medicine.symptom business Follow-Up Studies |
| Zdroj: | Brain Injury. 26:979-983 |
| ISSN: | 1362-301X 0269-9052 |
| DOI: | 10.3109/02699052.2012.660512 |
| Popis: | To evaluate the efficacy and the safety of repeated botulinum toxin type A (BT-A) injections in patients with severe acquired brain injury (ABI) and to gain a better knowledge of possible clinical or demographic characteristics associated with a better rehabilitation outcome.Prospective study with a 1-year follow-up period.Twenty-one patients with spasticity due to severe ABI and no further improving with rehabilitation treatment and oral anti-spastic drugs.Repeated BT-A injections associated to a rehabilitation programme.Barthel Index (BI), Modified Ashworth Score (MAS) and VAS score for pain subjective perception were recorded.At the end of the follow-up study, MAS, BI and VAS significantly improved. Despite the number of BT-A injections, a shorter interval between severe ABI onset and first BT-A treatment correlated to a better BI improvement. None of the patients experienced adverse events attributable to BT-A.BT-A was effective and safe in the treatment of spasticity in severe ABI patients, with a better functional outcome in those subjects treated earlier after spasticity onset. The lack of correlation between clinical outcome and number of injections suggests, in addition to a direct inhibition at the neuromuscular junction, a more distant BT-A long-term effect. |
| Databáze: | OpenAIRE |
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